Molecular data
| Physical form | Lyophilized powder blend |
|---|---|
| Available sizes | 10mg / 5mg / 5mg |
How it works
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PT-141
Melanocortin Receptors
PT-141 is a cyclic heptapeptide that binds MC3R and MC4R. Research has measured its activity in the central nervous system rather than in blood vessels, which separates it from other compounds studied in the same area.
- Cyclic seven amino acid structure
- MC3R and MC4R binding
- Central rather than vascular activity
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Oxytocin
OXTR Binding
Oxytocin is a nine amino acid neurohypophysial hormone closed by a disulfide bridge between residues 1 and 6, binding the oxytocin receptor OXTR.
- Nonapeptide with 1-6 disulfide
- OXTR agonist
- Behavioural endpoints in animal models
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Kisspeptin-10
KISS1R Signalling
Kisspeptin-10 is the active ten amino acid portion of kisspeptin-54. It binds KISS1R, and studies have measured hypothalamic signalling and how that signal moves down the reproductive hormone axis.
- Active fragment of kisspeptin-54
- KISS1R agonist
- Hypothalamic signalling endpoints
What the research shows
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Neuro
Melanocortin Signalling
PT-141 is characterised for MC3R and MC4R activity in central nervous system models.
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Endocrine
Neurohormone Studies
Oxytocin is a long-established reference ligand for the OXTR receptor.
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Endocrine
Reproductive Axis
Kisspeptin-10 is characterised for hypothalamic signalling through KISS1R.
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Methods
Parallel Protocols
One vial holds all three peptides under matched handling.
Specification
| Components | PT-141 + Oxytocin + Kisspeptin-10 |
|---|---|
| Content | 20 mg per vial (10 mg PT-141, 5 mg Oxytocin, 5 mg Kisspeptin-10) |
| PT-141 | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (bremelanotide) |
| Oxytocin | Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂, CAS 50-56-6 |
| Kisspeptin-10 | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂, CAS 374675-21-5 |
| Form | Lyophilized powder blend |
| Purity | ≥99% by HPLC |
| Appearance | White to off-white powder |
| Solubility | Water-soluble |
| Storage | -20°C, protected from light |
| Classification | Research use only |
Frequently asked questions
Why combine these three peptides?
All three are neuroendocrine signalling peptides studied in overlapping literature, though at three unrelated receptors: PT-141 at MC3R and MC4R, Oxytocin at OXTR, and Kisspeptin-10 at KISS1R. One vial holds all three under matched handling.
How does this differ from the PT-141 / Oxytocin two-peptide vial?
That vial holds 10 mg of each and no Kisspeptin. This one adds Kisspeptin-10 and supplies Oxytocin at 5 mg rather than 10 mg, for the same 20 mg total.
Has the combination been characterised as a single formulation?
No. Each peptide is characterised separately and no interaction data exists for the combination.
Why is Kisspeptin-10 listed rather than kisspeptin-54?
Kisspeptin-10 is the active ten amino acid portion of the longer kisspeptin-54 sequence, and is the form supplied here.
What purity is documented?
Each lot is analysed by reverse-phase HPLC and released at ≥99%, with a Certificate of Analysis.
How is it stored?
Store lyophilized at -20°C for long-term stability, protected from light and moisture, and avoid repeated freeze-thaw cycles.
Related monographs
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.