● In Stock
GHK-Cu
≥99% Purity | HPLC Verified
Price range: $40.00 through $55.00
PASSED
Sterility & Endotoxins
PASSED
Net Content & Purity
Purity:
≥99%
Store at
-20°C
Copper-binding tripeptide studied for collagen synthesis and tissue remodeling in preclinical research. Research use only.
Research Use OnlyNot for human or veterinary use. For in vitro laboratory research only.
| Size | 100mg, 50mg |
4000+
Genes Modulated
Gene expression reset toward health
70%
Collagen Increase
Type I & III vs controls
130+
Published Studies
Preclinical research papers
99%+
Purity Verified
HPLC tested, COA included
How GHK-Cu Works
A naturally occurring copper-binding tripeptide with broad regenerative properties
Copper Delivery
Copper Transport & Signaling
GHK-Cu chelates copper(II) ions and delivers them to cells, activating copper-dependent enzymes essential for collagen crosslinking, antioxidant defense, and tissue remodeling.
- High-affinity copper(II) binding
- Activates lysyl oxidase for collagen crosslinking
- Supports superoxide dismutase activity
Collagen Synthesis
ECM Remodeling & Repair
Stimulates fibroblasts to produce type I and III collagen, glycosaminoglycans, and decorin — rebuilding the extracellular matrix architecture in damaged tissue.
- 70% increase in collagen synthesis vs controls
- Glycosaminoglycan production enhanced
- Decorin synthesis for matrix organization
Gene Modulation
Genomic Reprogramming
Gene expression studies show GHK-Cu modulates 4,000+ human genes, resetting expression patterns toward a healthier, more youthful state. This is among the broadest gene-modulatory effects of any known peptide.
- 4,000+ genes modulated toward health
- Upregulates DNA repair genes
- Suppresses inflammatory gene expression
What Research Has Shown
Key preclinical findings from published studies
Research Applications
Primary areas of preclinical investigation
Dermatology
Skin Regeneration
Stimulates collagen, elastin, and glycosaminoglycan synthesis. Studied extensively in wound healing and anti-aging skin models.
Trichology
Hair Restoration
Increases hair follicle size, stimulates follicle growth, and supports hair cycle transition in preclinical models.
Genomics
Gene Expression
Modulates 4,000+ genes including DNA repair, antioxidant defense, and anti-inflammatory pathways toward healthier expression patterns.
Protective
Antioxidant Defense
Chelates free copper, reduces oxidative damage, and upregulates superoxide dismutase — the body's primary antioxidant enzyme.
Safety Profile from Research
Preclinical safety data
✓GHK-Cu is naturally present in human blood, saliva, and urine — concentration declines with age from ~200 ng/mL at age 20 to ~80 ng/mL at age 60.
✓Long history of topical use in cosmetic formulations with established safety profile.
✓No significant toxicity reported in preclinical studies at physiologically relevant concentrations.
✓Copper delivery is self-limiting — GHK-Cu releases copper to cells without causing copper overload.
⚠️ Injectable GHK-Cu is for in vitro research only. No completed clinical trials for injectable forms. Not for human therapeutic use.
Compound Information
Technical specifications
| Sequence | Gly-His-Lys-Cu(II) |
| Molecular Weight | 403.9 Da |
| Molecular Formula | C₁₄H₂₄CuN₆O₄ |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (lyophilized) | -20°C for up to 24 months |
| Storage (reconstituted) | 2–8°C, use within 30 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
Frequently Asked Questions
Common questions about GHK-Cu
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding tripeptide first isolated from human plasma in 1973 by Dr. Loren Pickart. It is found in human blood, saliva, and urine, with plasma levels declining from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60.
Preclinical research has demonstrated that GHK-Cu may promote wound healing and skin repair by stimulating collagen and glycosaminoglycan synthesis; attract immune and endothelial cells to injury sites; have anti-inflammatory and antioxidant properties; and modulate the expression of over 4,000 genes toward healthier patterns.
GHK-Cu is not FDA approved as a drug. It is available as a research peptide and is also found in some cosmetic formulations. Injectable forms are sold exclusively for in vitro research purposes.
In research settings, GHK-Cu is typically reconstituted in bacteriostatic water and administered subcutaneously in animal models. Common research dosages range from 1-10 mg/kg in preclinical studies.
GHK-Cu consists of three amino acids — glycine, histidine, and lysine — complexed with a copper(II) ion. The molecular formula is C₁₄H₂₄CuN₆O₄ with a molecular weight of approximately 403.9 Da. The histidine residue provides the primary copper-binding site.
Lyophilized GHK-Cu should be stored at -20°C for maximum stability (up to 24 months). After reconstitution, refrigerate at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles and protect from light.
Sources & References
PubMed
GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
2015
PubMed
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions
2012
PubMed
Tripeptide GHK induces programmed cell death in SH-SY5Y neuroblastoma cells
2014
Published research on this compound is available through PubMed and other scientific databases.
Certificate of Analysis
| Analysis Date: | Available on request |
| Lot Number: | Batch-specific |
| Purity: | >99% (HPLC) |
Third-Party Testing
- ✓ Identity verification (Mass Spectrometry)
- ✓ Purity analysis (HPLC)
- ✓ Sterility testing
- ✓ Endotoxin screening
Storage Conditions
- Lyophilized: Store at -20°C, protected from light
- Reconstituted: Store at 2-8°C, use within 30 days
- Stability: 24 months from manufacture date when stored properly
Handling Guidelines
- Use sterile technique when reconstituting
- Allow vial to reach room temperature before opening
- Reconstitute with bacteriostatic water or sterile saline
- Avoid repeated freeze-thaw cycles
RESEARCH INSIGHTS
3D Structure
GHK-Cu
This compound has been extensively studied in peer-reviewed literature. Eon Peptides provides this product exclusively for legitimate in-vitro research and analytical applications.
- • High-purity research compound
- • Full analytical documentation included
- • Third-party verification available
PRODUCT SPECIFICATIONS
LOT DATA
| Lot Number | Assigned on shipment |
| Verified Purity | >99% |
| Quantity | 5mg |
MOLECULAR DATA
| Molecular Formula | Available on request |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
