Skin Regeneration
Stimulates collagen, elastin, and glycosaminoglycan synthesis. Studied extensively in wound healing and anti-aging skin models.
Pickart et al. 2015≥99% Purity
GHK-Cu
A copper peptide famous for collagen, skin renewal, and healing
$40.00$20.00/vial with BOGO
USA madecGMP facility
SizeQuantityBuy 1 Get 1 Free · auto-appliedAdd 2+ items to cart to activate the discount
Free Shipping on orders over $200
PASSEDSterility & Endotoxins
PASSEDNet Content & Purity
Researchers also added
Authenticity
Every vial is QR-authenticated
Scan the QR code on any vial to verify its batch, COA, and origin in seconds. Secure traceability from our lab to your bench.
About this compound
GHK-Cu is a naturally occurring copper peptide famous in skin and repair research for stimulating collagen, firming and renewing skin, and supporting wound healing.
Copper-binding tripeptide
- Formula
- C₁₄H₂₄CuN₆O₄
- Molecular weight
- 403.9 g/mol
- Form
- Lyophilized powder
- CAS / ID
- 49557-75-7
0+
Genes Modulated
Gene expression reset toward health
0%
Collagen Increase
Type I & III vs controls
0+
Published Studies
Preclinical research papers
0
Research Areas
Skin Regeneration · Hair Restoration · Gene Expression & more
How It Works
How GHK-Cu works
The pathways GHK-Cu acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Copper Transport & Signaling
Copper Delivery
GHK-Cu chelates copper(II) ions and delivers them to cells, activating copper-dependent enzymes essential for collagen crosslinking, antioxidant defense, and tissue remodeling.
- High-affinity copper(II) binding
- Activates lysyl oxidase for collagen crosslinking
- Supports superoxide dismutase activity
ECM Remodeling & Repair
Collagen Synthesis
Stimulates fibroblasts to produce type I and III collagen, glycosaminoglycans, and decorin — rebuilding the extracellular matrix architecture in damaged tissue.
- 70% increase in collagen synthesis vs controls
- Glycosaminoglycan production enhanced
- Decorin synthesis for matrix organization
Genomic Reprogramming
Gene Modulation
Gene expression studies show GHK-Cu modulates 4,000+ human genes, resetting expression patterns toward a healthier, more youthful state. This is among the broadest gene-modulatory effects of any known peptide.
- 4,000+ genes modulated toward health
- Upregulates DNA repair genes
- Suppresses inflammatory gene expression
Uses & Applications
What GHK-Cu is researched for
The main areas GHK-Cu is being studied for — and the study-reported figures behind them.
Hair Restoration
Increases hair follicle size, stimulates follicle growth, and supports hair cycle transition in preclinical models.
Pickart et al. 2012Gene Expression
Modulates 4,000+ genes including DNA repair, antioxidant defense, and anti-inflammatory pathways toward healthier expression patterns.
Pickart & Margolina 2014Antioxidant Defense
Chelates free copper, reduces oxidative damage, and upregulates superoxide dismutase — the body's primary antioxidant enzyme.
Maquart et al. 2014Molecular Structure
The GHK-Cu molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
Copper-coordination complex
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of GHK-Cu is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Sequence | Gly-His-Lys-Cu(II) |
| Molecular Weight | 403.9 Da |
| Molecular Formula | C₁₄H₂₄CuN₆O₄ |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (Lyophilized) | -20°C for up to 24 months |
| Storage (Reconstituted) | 2–8°C, use within 30 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
FAQ
Common questions about GHK-Cu
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding tripeptide first isolated from human plasma in 1973 by Dr. Loren Pickart. It is found in human blood, saliva, and urine, with plasma levels declining from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60.
Preclinical research has demonstrated that GHK-Cu may promote wound healing and skin repair by stimulating collagen and glycosaminoglycan synthesis; attract immune and endothelial cells to injury sites; have anti-inflammatory and antioxidant properties; and modulate the expression of over 4,000 genes toward healthier patterns.
GHK-Cu is not FDA approved as a drug. It is available as a research peptide and is also found in some cosmetic formulations. Injectable forms are sold exclusively for in vitro research purposes.
In research settings, GHK-Cu is typically reconstituted in bacteriostatic water and administered subcutaneously in animal models. Common research dosages range from 1-10 mg/kg in preclinical studies.
GHK-Cu consists of three amino acids — glycine, histidine, and lysine — complexed with a copper(II) ion. The molecular formula is C₁₄H₂₄CuN₆O₄ with a molecular weight of approximately 403.9 Da. The histidine residue provides the primary copper-binding site.
Lyophilized GHK-Cu should be stored at -20°C for maximum stability (up to 24 months). After reconstitution, refrigerate at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles and protect from light.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
PubMed
[2]GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
View source PubMed
[3]The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions
View source PubMed
[4]Tripeptide GHK induces programmed cell death in SH-SY5Y neuroblastoma cells
View source PubMed
GHK and DNA: Resetting the human genome to health
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.