Showing 6 compounds in GHRH Analogues and GH Secretagogues · all 31 compounds
About ghrh analogues and gh secretagogues
This class groups peptides by the receptor they are studied against. Sermorelin, tesamorelin and both CJC-1295 forms are analogues of the first 29 or 44 residues of growth hormone-releasing hormone and are studied at the GHRH receptor. Ipamorelin is a pentapeptide studied at the ghrelin receptor GHSR-1a. The CJC/IPA blend pairs one of each in a single vial.
The compounds differ structurally in chain length and modification. Sermorelin is GHRH(1-29) with an amidated C-terminus. Tesamorelin is GHRH(1-44) with a trans-3-hexenoic acid modification at the N-terminus. CJC-1295 without DAC is a modified GRF(1-29) with four amino acid substitutions that resist protease cleavage; the DAC form adds a maleimidopropionic acid group at lysine 8 that binds serum albumin in vitro. Ipamorelin is five residues.
Certificates for this class report HPLC purity and identity per lot in the same way as every other compound on the site. Sequence length matters for identity testing: the 44-residue tesamorelin and the 29- and 30-residue GHRH analogues are confirmed by mass against their expected values, and the five-residue ipamorelin by mass and retention.
Regulatory note: peptides in this class appear on the World Anti-Doping Agency prohibited list under peptide hormones and growth factors, and an approved pharmaceutical formulation of tesamorelin exists for one indication. The research-grade material sold here is for in vitro research only and is not that product. Each product page carries its own status line and its monograph in the research library.
Questions
What is the difference between a GHRH analogue and a GH secretagogue?
A GHRH analogue is a modified fragment of growth hormone-releasing hormone studied at the GHRH receptor; a GH secretagogue such as ipamorelin is studied at the ghrelin receptor GHSR-1a. They are different receptors and different peptide families.
What is the difference between CJC-1295 with and without DAC?
The DAC form carries a maleimidopropionic acid group on lysine 8 that binds serum albumin in vitro; the non-DAC form (modified GRF 1-29) lacks it. Both share the same four protease-resistant substitutions.
How are these compounds tested?
HPLC purity and identity confirmation per lot by a third-party laboratory, with the certificate linked from each product page and the COA library.
Are any of these approved pharmaceuticals?
An approved pharmaceutical formulation of tesamorelin exists for one indication. The research-grade compounds sold here are not that product; they are for in vitro research only.
Other collections
For laboratory research use only. Not for human or veterinary use. Every lot ships with a third-party Certificate of Analysis.