Molecular data
| Sequence length | 13 residues |
|---|---|
| Physical form | Lyophilized powder |
| Available sizes | 5mg |
How it works
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Receptor
Melanocortin Receptor Binding
Melanotan I is characterised as an α-MSH analog binding the melanocortin receptor family, with MC1R the principal studied target in pigmentation research.
- MC1R engagement
- α-MSH analog
- Melanocortin receptor family
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Cellular
Melanogenesis Endpoints
Melanin synthesis in melanocyte culture is the standard measured endpoint in the published MC1R literature.
- Melanocyte culture models
- Melanin synthesis endpoints
- Dose-response characterisation
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Structure
Linear vs Cyclic
Melanotan I is linear where Melanotan II is cyclic. The structural difference is associated with differing receptor-selectivity profiles across the melanocortin family.
- Linear backbone
- Differing selectivity profile
- Studied alongside Melanotan II
What the research shows
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Dermatology
Pigmentation Models
Melanin synthesis in melanocyte culture is the principal studied endpoint.
-
Endocrinology
Melanocortin Signalling
Studied as an α-MSH analog across the melanocortin receptor family.
-
Methods
Comparative Work
Frequently studied alongside the cyclic analog Melanotan II for selectivity comparison.
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Analytical
Reference Material
Used as a characterised melanocortin-agonist reference in assay development.
Specification
| Chemical Name | Melanotan I (α-MSH analog) |
|---|---|
| Content | 5 mg per vial |
| Principal Target | Melanocortin-1 receptor (MC1R) |
| Structure | Linear analog (cf. cyclic Melanotan II) |
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC |
| Appearance | White to off-white powder |
| Solubility | Water-soluble |
| Storage | -20°C, protected from light |
| Classification | Research use only |
Frequently asked questions
How does Melanotan I differ from Melanotan II?
Melanotan I is linear; Melanotan II is cyclic. The structural difference is associated with differing selectivity across the melanocortin receptor family. Both are studied in melanocortin research.
What is the principal studied target?
The melanocortin-1 receptor (MC1R), characterised in pigmentation research using melanocyte culture models.
Is a molecular weight listed?
The molecular weight will be published here from the lot's Certificate of Analysis rather than quoted from a secondary source.
What purity is documented?
Each lot is analysed by reverse-phase HPLC and released at ≥99%, with a Certificate of Analysis.
How is it stored?
Store lyophilized at -20°C for long-term stability, protected from light and moisture, and avoid repeated freeze-thaw cycles.
Related monographs
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.