Showing 3 compounds in Copper Peptides · all 31 compounds
About copper peptides
A copper peptide is a peptide that coordinates a copper(II) ion. The one carried here is GHK-Cu: the tripeptide glycyl-L-histidyl-L-lysine, isolated from human plasma in 1973, bound to one Cu(II) ion through its terminal amine, a deprotonated amide nitrogen and the histidine imidazole. The complex is a blue lyophilised powder; the free tripeptide is white.
GHK-Cu is sold as a single compound in 50 mg and 100 mg vials and is the largest component by mass in the GLOW and KLOW blends, which is why those vials are also blue. The GHK-Cu monograph documents the chemistry, the studies indexed for it and its certificates.
Testing a copper complex has one step more than testing a plain peptide. HPLC purity is measured on the peptide ligand under acidic conditions, where the complex dissociates on column; identity is confirmed against the expected mass; and the copper is evidenced by the appearance recorded on the certificate and, where reported, by a metal assay. Certificates in the archive for GHK-Cu lots report purities in the 99.5 to 99.95 percent range.
Copper-binding peptides compete with other chelators and with histidine-containing peptides for the metal in solution, which is relevant to analytical work on blends and to any assay design that includes EDTA or other chelating buffers.
Questions
What is GHK-Cu?
The copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), a blue lyophilised powder with a nominal molecular weight of about 403.9 g/mol for the complex.
Is GHK the same as GHK-Cu?
No. GHK is the free tripeptide; GHK-Cu is its copper complex. Identity testing on a GHK-Cu lot checks for the complex.
Which blends contain GHK-Cu?
GLOW (with BPC-157 and TB-500) and KLOW (the same three plus KPV). GHK-Cu is the largest component by mass in both.
Why are copper peptide vials blue?
Copper(II) coordinated by nitrogen donors absorbs red light and appears blue. A white powder sold as a copper complex would not contain the copper.
Other collections
For laboratory research use only. Not for human or veterinary use. Every lot ships with a third-party Certificate of Analysis.