Molecular data
| Molecular formula | C63H83N17O14 |
|---|---|
| Molecular weight | 1302.5 Da |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Sequence length | 10 residues |
| CAS / identifier | 374675-21-5 |
| Physical form | White lyophilized powder |
| Available sizes | 10mg |
How it works
KISS1R / GPR54 Activation
Kisspeptin-10 is the shortest active fragment of the KISS1 gene product and binds KISS1R (GPR54) on hypothalamic GnRH neurons — the most potent known endogenous trigger of GnRH neuron activity.
GnRH Pulse Generation
Receptor activation evokes pulsatile GnRH secretion into the hypophyseal portal circulation, increasing both the frequency and amplitude of GnRH pulses rather than simply raising output.
Gonadotropin Release
Downstream of GnRH, the pituitary releases luteinizing hormone (robust) and follicle-stimulating hormone (more modest), letting researchers probe upstream control of the gonadal axis.
What the research shows
GnRH Axis Probing
Used to evoke discrete LH pulses, enabling characterization of GnRH pulsatility and pituitary responsiveness in controlled models.
Gonadotropin Stimulation
Studied as a stimulus of endogenous LH/FSH to distinguish hypothalamic from pituitary components of reproductive dysfunction.
Pubertal Signaling
Investigated for the role of KISS1/GPR54 signaling in the onset and timing of puberty.
Specification
| Also Known As | KP-10, Metastin 45-54, Kisspeptin-112-121 |
|---|---|
| Type | Decapeptide — KISS1R/GPR54 agonist |
| CAS Number | 374675-21-5 |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1,302.5 g/mol |
| Amino Acid Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Physical Appearance | White lyophilized powder |
| Purity | ≥98% (HPLC) |
| Content | 10 mg per vial |
Frequently asked questions
What is Kisspeptin-10?
Kisspeptin-10 (KP-10) is a synthetic decapeptide corresponding to the C-terminal active fragment of the kisspeptin family encoded by the KISS1 gene. It is a high-affinity agonist of the KISS1R (GPR54) receptor.
How does it differ from Kisspeptin-54?
Kisspeptin-54 is the longer parent peptide; Kisspeptin-10 retains the C-terminal decapeptide that carries full receptor activity, with a shorter sequence and faster in-vivo clearance.
What is GPR54 / KISS1R?
It is the G-protein-coupled receptor for kisspeptins, expressed on GnRH neurons; its activation is essential for normal reproductive-axis function.
How is it stored and reconstituted?
Supplied as a lyophilized powder; store at -20°C. For laboratory use it is typically reconstituted with bacteriostatic or sterile water. Research use only.
Literature
- Cell Biology KiSS-1 encodes kisspeptins, natural ligands of GPR54
- Clinical Kisspeptin stimulates the hypothalamic-pituitary-gonadal axis in humans
- Review Kisspeptins and reproduction: physiological roles & regulation
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.