GnRH Axis Probing
Used to evoke discrete LH pulses, enabling characterization of GnRH pulsatility and pituitary responsiveness in controlled models.
≥99% Purity
Kisspeptin
Reproductive Hormone Studies
$75.00$37.50/vial with BOGO
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PASSEDSterility & Endotoxins
PASSEDNet Content & Purity
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About this compound
Kisspeptin-10 is a ten amino acid peptide. It is the active piece of a longer peptide called kisspeptin-54. It binds a receptor named KISS1R. Studies have measured what happens in the hypothalamus after it binds, and how that signal moves down the reproductive hormone axis. Its discovery changed how the field understood where that signal begins.
Decapeptide KISS1R/GPR54 agonist
- Formula
- C63H83N17O14
- Molecular weight
- 1302.5 g/mol
- Form
- White lyophilized powder
- CAS / ID
- 374675-21-5
0
Amino Acids
Decapeptide (KP-10)
GPR0
Target Receptor
KISS1R high-affinity agonist
0.0
Molecular Weight
C63H83N17O14
<0 min
Plasma Half-Life
Rapid clearance in vivo
How It Works
How Kisspeptin works
The pathways Kisspeptin acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
KISS1R / GPR54 Activation
GPR54 Agonist
Kisspeptin-10 is the shortest active fragment of the KISS1 gene product and binds KISS1R (GPR54) on hypothalamic GnRH neurons — the most potent known endogenous trigger of GnRH neuron activity.
GnRH Pulse Generation
GnRH ↑
Receptor activation evokes pulsatile GnRH secretion into the hypophyseal portal circulation, with both the frequency and amplitude of GnRH pulses measured rather than output alone.
Gonadotropin Release
LH / FSH ↑
Downstream of GnRH, the pituitary releases luteinizing hormone (robust) and follicle-stimulating hormone (more modest), letting researchers probe upstream control of the gonadal axis.
Uses & Applications
What Kisspeptin is researched for
The main areas Kisspeptin is being studied for — and the study-reported figures behind them.
Gonadotropin Response
Studied as a stimulus of endogenous LH/FSH to distinguish hypothalamic from pituitary components of reproductive dysfunction.
Pubertal Signaling
Investigated for the role of KISS1/GPR54 signaling in the onset and timing of puberty.
Molecular Structure
The Kisspeptin molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C63H83N17O14
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of Kisspeptin is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Also Known As | KP-10, Metastin 45-54, Kisspeptin-112-121 |
| Type | Decapeptide — KISS1R/GPR54 agonist |
| CAS Number | 374675-21-5 |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1,302.5 g/mol |
| Amino Acid Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Physical Appearance | White lyophilized powder |
| Purity | ≥99% (HPLC) |
| Content | 10 mg per vial |
FAQ
Common questions about Kisspeptin
Kisspeptin-10 (KP-10) is a synthetic decapeptide corresponding to the C-terminal active fragment of the kisspeptin family encoded by the KISS1 gene. It is a high-affinity agonist of the KISS1R (GPR54) receptor.
Kisspeptin-54 is the longer parent peptide; Kisspeptin-10 retains the C-terminal decapeptide that carries full receptor activity, with a shorter sequence and faster in-vivo clearance.
It is the G-protein-coupled receptor for kisspeptins, expressed on GnRH neurons; its activation is essential for normal reproductive-axis function.
Supplied as a lyophilized powder; store at -20°C, protected from light and moisture. Research use only.
For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.