Preclinical study index · Research use only

Semax: preclinical and in-vitro studies

8 published studies on Semax, limited by rule to animal models and cell-based (in vitro) work indexed in PubMed, spanning 2018 to 2025 across 5 journals. Human trials, case reports and literature overviews are excluded. Titles appear as published; each links to its PubMed record and, where one is registered, its DOI.

  • 8studies listed
  • 8with an animal model
  • 3with in-vitro work
  • 2018 to 2025publication years
  • 5journals

Evidence table

#YearStudyJournalModelRecord
1 2025 The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain NeuronsPMID 41171324 Bulletin of experimental biology and medicine Rats model and in vitro PubMed · DOI
2 2025 Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female micePMID 40692165 British journal of pharmacology Rats and Mice model and in vitro PubMed · DOI
3 2024 Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stressPMID 39442746 European journal of pharmacology Rats model PubMed · DOI
4 2021 Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white ratsPMID 33418449 Neuropeptides Rats model PubMed · DOI
5 2021 Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)PMID 33459919 Bulletin of experimental biology and medicine Rats model PubMed · DOI
6 2021 Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-ReperfusionPMID 34201112 International journal of molecular sciences Rats model PubMed · DOI
7 2020 Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint StressPMID 32737723 Bulletin of experimental biology and medicine Rats model PubMed · DOI
8 2018 Modulation of GABA- and Glycine-Activated Ionic Currents with Semax in Isolated Cerebral NeuronsPMID 29577196 Bulletin of experimental biology and medicine Rats model and in vitro PubMed · DOI

Studies by model

  • Rats · 8 studies
  • In vitro · 3 studies
  • Mice · 1 study

What this index does not include

Human research of any kind: publications typed by PubMed as human studies or case reports, and papers whose titles or abstracts describe human subjects, are removed by rule. Literature overviews, meta-analyses, editorials and letters are removed because they summarise rather than report. Papers whose titles contain usage or outcome language that would not pass this site's research-use-only copy rules are dropped rather than reworded, since a published title is a fact that cannot be edited.

Nothing on this page is a statement about effects in humans, a recommendation, or a description of the material supplied. Semax is supplied for laboratory research only.

How this index is built

PubMed is searched on the names the literature uses for Semax (Semax), restricted to records indexed to an animal or cell model, in English, with an abstract. Clinical publication types, human-subject language and overview-type publications are excluded. The compound must be named in the title. Candidates are ranked by title match, indexing quality and year; the shortlist is read by a person before it is published, and a small blocklist holds records rejected on that read. The list was resolved on 2026-10-12 and is re-run deliberately, never on a timer.

Questions

Are there human studies of Semax in this index?

No, by design. This index lists animal and cell-based research only. Publications typed as human studies, case reports or literature overviews, and papers whose titles or abstracts describe human subjects, are excluded by rule before anything is listed. Eon Peptides supplies Semax for laboratory research and makes no statement about use in humans.

Which research models appear most often for Semax?

Across the 8 studies listed: Rats (8), In vitro (3), Mice (1). A model label is taken from PubMed's indexing of each paper, or from its title and abstract when the record is too new to be indexed. It describes the study, not the material.

How are the studies selected?

A PubMed search on the published names of the compound (Semax) is filtered to records indexed to an animal or cell model, with clinical publication types, human-subject language and overview-type publications removed. The compound must be named in the title. Remaining records are ranked by title match, indexing quality and year, and the top 8 are listed after a manual read. The list was resolved against PubMed on 2026-10-12.

Does a listing here say anything about the Semax Eon Peptides sells?

No. A listing records that a study was published and what it examined. It says nothing about the properties, quality or intended use of any material. What Eon Peptides does document about its own Semax is on the certificate pages: lot-level identity and purity results from independent laboratories.

Related pages

For research use only. Not for human or veterinary use. Preclinical and in-vitro studies only: animal models and cell-based work indexed in PubMed. Human trials, case reports and literature overviews are excluded by rule.