Memory & Learning
Enhances cognitive function, memory consolidation, and attention in animal models. Approved as a nootropic in Russia since 2011.
Ashmarin et al. 2006≥99% Purity
Semax
A nootropic peptide for focus, memory, and brain support
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About this compound
Semax is a nootropic peptide researched for boosting focus, memory, and mental clarity, and for protecting the brain under stress and after injury.
Synthetic heptapeptide analog of ACTH(4-10)
- Formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol
- Form
- Lyophilized Powder
0.0×
BDNF Increase
Brain-derived neurotrophic factor
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Amino Acids
ACTH(4-10) synthetic analog
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Approved in Russia
Prescription nootropic since 2011
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Research Areas
Memory & Learning · Stroke Recovery · BDNF & Nerve Growth & more
How It Works
How Semax works
The pathways Semax acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
BDNF Modulation
Neurotrophic
Semax increases brain-derived neurotrophic factor (BDNF) levels by up to 1.4-fold in specific brain regions, supporting neuronal survival, growth, and synaptic plasticity.
- Increases BDNF expression up to 1.4×
- Supports neuronal survival and growth
- Enhances synaptic plasticity
Serotonin & Dopamine Modulation
Neurotransmitter
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
- Modulates serotonin metabolism
- Influences dopaminergic signaling
- Affects noradrenergic pathways
Ischemic Protection
Neuroprotective
In ischemic stroke models, Semax demonstrates neuroprotective effects by reducing infarct volume, modulating inflammatory gene expression, and promoting neuronal survival under oxygen deprivation.
- Reduces infarct volume in stroke models
- Anti-inflammatory gene modulation
- Protects neurons from oxidative stress
Uses & Applications
What Semax is researched for
The main areas Semax is being studied for — and the study-reported figures behind them.
Stroke Recovery
Reduces ischemic brain damage and promotes neuronal survival in cerebral ischemia models. Used clinically in Russia for stroke recovery.
Gusev et al. 2010BDNF & Nerve Growth
Modulates expression of neurotrophins and their receptors, supporting neuronal plasticity and regeneration pathways.
Agapova et al. 2010Immune Modulation
Reduces pro-inflammatory cytokines and modulates oxidative stress-related gene expression in hippocampal tissue.
Agapova et al. 2011Molecular Structure
The Semax molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C37H51N9O10S
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of Semax is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Strength | 10mg |
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.93 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | Synthetic analog of ACTH(4-10) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (Lyophilized) | -20°C for up to 24 months |
| Storage (Reconstituted) | 2–8°C, use within 21 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
| Appearance | White to off-white powder |
FAQ
Common questions about Semax
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
Research has demonstrated that Semax may increase BDNF levels by up to 1.4-fold, modulate serotonergic and dopaminergic systems, have neuroprotective effects in ischemic stroke models, enhance cognitive function and memory in animal studies, and display anti-inflammatory properties.
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, increasing stability and resistance to enzymatic degradation. This results in a longer half-life and potentially enhanced bioavailability compared to standard Semax.
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). After reconstitution, store at 2-8°C and use within 21 days. Protect from heat and direct light.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
PubMed
[2]Semax, an ACTH(4-10) analogue with cognitive-enhancing properties
View source PubMed
[3]Neuroprotective effects of Semax in conditions of cerebral ischemia
View source PubMed
[4]Semax modulates the expression of neurotrophins and their receptors
View source PubMed
Molecular mechanisms underlying effects of Semax on hippocampal gene expression
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.