● In Stock
Semax
≥99% Purity | HPLC Verified
$60.00
PASSED
Sterility & Endotoxins
PASSED
Net Content & Purity
Purity:
≥99%
Store at
-20°C
ACTH(4-7) analog studied for cognitive enhancement and neuroprotection in clinical research. Research use only.
Research Use OnlyNot for human or veterinary use. For in vitro laboratory research only.
| Strength | 5mg |
| molecular_formula | C37H51N9O10S |
| Molecular Weight | 813.93 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
1.4×
BDNF Increase
Brain-derived neurotrophic factor
7
Amino Acids
ACTH(4-10) synthetic analog
2011
Approved in Russia
Prescription nootropic since 2011
99%+
Purity Verified
HPLC tested, COA included
How Semax Works
Neuropeptide derived from ACTH with cognitive-enhancing and neuroprotective properties
Neurotrophic
BDNF Modulation
Semax increases brain-derived neurotrophic factor (BDNF) levels by up to 1.4-fold in specific brain regions, supporting neuronal survival, growth, and synaptic plasticity.
- Increases BDNF expression up to 1.4×
- Supports neuronal survival and growth
- Enhances synaptic plasticity
Neurotransmitter
Serotonin & Dopamine Modulation
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
- Modulates serotonin metabolism
- Influences dopaminergic signaling
- Affects noradrenergic pathways
Neuroprotective
Ischemic Protection
In ischemic stroke models, Semax demonstrates neuroprotective effects by reducing infarct volume, modulating inflammatory gene expression, and promoting neuronal survival under oxygen deprivation.
- Reduces infarct volume in stroke models
- Anti-inflammatory gene modulation
- Protects neurons from oxidative stress
What Research Has Shown
Key findings from preclinical and clinical studies
Research Applications
Areas of active preclinical and clinical investigation
Cognitive
Memory & Learning
Enhances cognitive function, memory consolidation, and attention in animal models. Approved as a nootropic in Russia since 2011.
Neuroprotection
Stroke Recovery
Reduces ischemic brain damage and promotes neuronal survival in cerebral ischemia models. Used clinically in Russia for stroke recovery.
Neurotrophic
BDNF & Nerve Growth
Modulates expression of neurotrophins and their receptors, supporting neuronal plasticity and regeneration pathways.
Anti-Inflammatory
Immune Modulation
Reduces pro-inflammatory cytokines and modulates oxidative stress-related gene expression in hippocampal tissue.
Safety Profile from Research
Clinical and preclinical safety data
✓Approved as a prescription medication in Russia and CIS countries since 2011 with established clinical safety data.
✓Derived from ACTH(4-10), a naturally occurring fragment of adrenocorticotropic hormone with no corticosteroid activity.
✓Does not affect cortisol levels — unlike ACTH itself, Semax has no adrenal stimulating properties.
✓No significant adverse effects reported in published Russian clinical literature at approved dosages.
⚠️ Semax is not FDA approved in the United States. Available for in vitro research only. Not for human consumption outside approved jurisdictions.
Compound Information
Technical specifications
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Molecular Weight | 813.93 Da |
| Origin | Synthetic analog of ACTH(4-10) |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (lyophilized) | -20°C for up to 24 months |
| Storage (reconstituted) | 2–8°C, use within 21 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
Frequently Asked Questions
Common questions about Semax
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
Research has demonstrated that Semax may increase BDNF levels by up to 1.4-fold, modulate serotonergic and dopaminergic systems, have neuroprotective effects in ischemic stroke models, enhance cognitive function and memory in animal studies, and display anti-inflammatory properties.
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, increasing stability and resistance to enzymatic degradation. This results in a longer half-life and potentially enhanced bioavailability compared to standard Semax.
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). After reconstitution, store at 2-8°C and use within 21 days. Protect from heat and direct light.
Sources & References
PubMed
Molecular mechanisms underlying effects of Semax on hippocampal gene expression
2011
Published research on this compound is available through PubMed and other scientific databases.
Certificate of Analysis
| Analysis Date: | Available on request |
| Lot Number: | Batch-specific |
| Purity: | >99% (HPLC) |
Third-Party Testing
- ✓ Identity verification (Mass Spectrometry)
- ✓ Purity analysis (HPLC)
- ✓ Sterility testing
- ✓ Endotoxin screening
Storage Conditions
- Lyophilized: Store at -20°C, protected from light
- Reconstituted: Store at 2-8°C, use within 30 days
- Stability: 24 months from manufacture date when stored properly
Handling Guidelines
- Use sterile technique when reconstituting
- Allow vial to reach room temperature before opening
- Reconstitute with bacteriostatic water or sterile saline
- Avoid repeated freeze-thaw cycles
RESEARCH INSIGHTS
3D Structure
Semax
This compound has been extensively studied in peer-reviewed literature. Eon Peptides provides this product exclusively for legitimate in-vitro research and analytical applications.
- • High-purity research compound
- • Full analytical documentation included
- • Third-party verification available
PRODUCT SPECIFICATIONS
LOT DATA
| Lot Number | Assigned on shipment |
| Verified Purity | >99% |
| Quantity | 5mg |
MOLECULAR DATA
| Molecular Formula | Available on request |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
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