Molecular data
| Molecular formula | C37H51N9O10S |
|---|---|
| Molecular weight | 813.93 Da |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Sequence length | 7 residues |
| Physical form | Lyophilized Powder |
| Available sizes | 10mg |
How it works
BDNF Modulation
Semax increases brain-derived neurotrophic factor (BDNF) levels by up to 1.4-fold in specific brain regions, supporting neuronal survival, growth, and synaptic plasticity.
- Increases BDNF expression up to 1.4×
- Supports neuronal survival and growth
- Enhances synaptic plasticity
Serotonin & Dopamine Modulation
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
- Modulates serotonin metabolism
- Influences dopaminergic signaling
- Affects noradrenergic pathways
Ischemic Protection
In ischemic stroke models, Semax demonstrates neuroprotective effects by reducing infarct volume, modulating inflammatory gene expression, and promoting neuronal survival under oxygen deprivation.
- Reduces infarct volume in stroke models
- Anti-inflammatory gene modulation
- Protects neurons from oxidative stress
What the research shows
Memory & Learning
Enhances cognitive function, memory consolidation, and attention in animal models. Approved as a nootropic in Russia since 2011.
Ashmarin et al. 2006
Stroke Recovery
Reduces ischemic brain damage and promotes neuronal survival in cerebral ischemia models. Used clinically in Russia for stroke recovery.
Gusev et al. 2010
BDNF & Nerve Growth
Modulates expression of neurotrophins and their receptors, supporting neuronal plasticity and regeneration pathways.
Agapova et al. 2010
Immune Modulation
Reduces pro-inflammatory cytokines and modulates oxidative stress-related gene expression in hippocampal tissue.
Agapova et al. 2011
Specification
| Strength | 10mg |
|---|---|
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.93 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | Synthetic analog of ACTH(4-10) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (lyophilized) | -20°C for up to 24 months |
| Storage (reconstituted) | 2–8°C, use within 21 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
| Appearance | White to off-white powder |
Frequently asked questions
What is Semax and where does it come from?
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
What has research shown about Semax?
Research has demonstrated that Semax may increase BDNF levels by up to 1.4-fold, modulate serotonergic and dopaminergic systems, have neuroprotective effects in ischemic stroke models, enhance cognitive function and memory in animal studies, and display anti-inflammatory properties.
Is Semax FDA approved?
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
How does Semax differ from N-Acetyl Semax?
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, increasing stability and resistance to enzymatic degradation. This results in a longer half-life and potentially enhanced bioavailability compared to standard Semax.
How should Semax be stored?
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). After reconstitution, store at 2-8°C and use within 21 days. Protect from heat and direct light.
Literature
- PubMed Semax, an ACTH(4-10) analogue with cognitive-enhancing properties
- PubMed Neuroprotective effects of Semax in conditions of cerebral ischemia
- PubMed Semax modulates the expression of neurotrophins and their receptors
- PubMed Molecular mechanisms underlying effects of Semax on hippocampal gene expression
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.