Growth Hormone Axis
Used as a research probe of pituitary GH secretory reserve; the GHRH stimulation test has historically been employed to assess somatotroph function.
GHRH stimulation literature≥99% Purity
Sermorelin
Prompts your body to make its own growth hormone naturally
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PASSEDSterility & Endotoxins
PASSEDNet Content & Purity
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About this compound
Sermorelin is a growth-hormone-releasing peptide researched for prompting the body to make its own growth hormone naturally — supporting recovery, sleep, and healthy aging while keeping the body's normal hormonal rhythm intact.
Growth hormone-releasing hormone (GHRH) analog; N-terminal 29-amino-acid fragment of human GHRH
- Formula
- C149H246N44O42S
- Molecular weight
- 3357.93 g/mol
- Form
- Lyophilized powder
- CAS / ID
- 86168-78-7
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Amino Acids
GHRH(1–29) active fragment
0.00
Molecular Weight
g/mol (acetate salt)
GH↑
Stimulates Release
Endogenous & pulsatile
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Research Areas
Growth Hormone Axis · Lean Mass & Adiposity · Slow-Wave Sleep & more
How It Works
How Sermorelin works
The pathways Sermorelin acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
GHRH Receptor Agonism
GHRH-R
Sermorelin binds growth hormone-releasing hormone receptors on anterior-pituitary somatotrophs, stimulating the synthesis and pulsatile release of endogenous growth hormone rather than supplying it exogenously.
- Activates pituitary somatotrophs
- Pulsatile GH release
- Endogenous secretion
Downstream IGF-1 Signaling
GH → IGF-1
Increased growth hormone drives hepatic production of insulin-like growth factor 1 (IGF-1), the principal mediator of GH's anabolic and metabolic effects on muscle, bone, connective tissue, and lipid metabolism.
- Hepatic IGF-1 synthesis
- Protein anabolism
- Lipolytic signaling
Preserved Physiologic Rhythm
Feedback
Because stimulation acts upstream at the pituitary, GH output remains subject to somatostatin and IGF-1 negative feedback, helping maintain a natural secretory rhythm instead of a fixed exogenous level.
- Somatostatin-regulated
- Negative feedback intact
- Natural pulsatility
Stimulates, Not Replaces
Upstream
Unlike recombinant HGH, which delivers growth hormone directly, Sermorelin prompts the pituitary to release its own GH — preserving the hypothalamic–pituitary axis and its regulatory checkpoints.
- Works upstream of GH
- HP axis preserved
- Self-limiting response
Uses & Applications
What Sermorelin is researched for
The main areas Sermorelin is being studied for — and the study-reported figures behind them.
Lean Mass & Adiposity
GH secretagogues are studied for their influence on lean body mass, fat mass, and metabolic rate in models of age- or disease-related GH decline.
Body-composition researchSlow-Wave Sleep
Endogenous GH release is tightly coupled to slow-wave sleep, so GHRH analogs are studied to explore the link between the somatotropic axis and sleep architecture.
Sleep-axis researchSomatopause
Age-related decline in GH and IGF-1 — termed somatopause — is modeled with GHRH analogs to investigate restoration of more youthful secretory patterns.
Aging-axis researchMolecular Structure
The Sermorelin molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C149H246N44O42S
How Long It Lasts
Duration & clearance
How Sermorelin clears from circulation, modeled from its documented ~~10–20 minutes (plasma) half-life. The curve draws as you scroll.
Sermorelin · ~~10–20 minutes (plasma)
Reference · rapid clearance
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of Sermorelin is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Compound Class | Growth hormone-releasing hormone (GHRH) analog |
| Research Name | Sermorelin (GHRH 1–29) |
| Sequence | N-terminal 29-amino-acid fragment of human GHRH |
| Target | GHRH receptor (pituitary somatotrophs) |
| Form | Lyophilized powder |
| Molecular Weight | 3,357.93 g/mol |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Half-Life | ~10–20 minutes (plasma) |
| Storage (Lyophilized) | -20°C for long-term stability |
| Storage (Reconstituted) | 2–8°C, use within 14 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
| Appearance | White to off-white powder |
| Quantity | 5mg |
| Stability | 24 months from manufacture date when stored properly |
FAQ
Common questions about Sermorelin
Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH) — the shortest fully active fragment. It stimulates the pituitary to secrete the body's own growth hormone in a natural, pulsatile fashion.
Recombinant HGH supplies growth hormone directly, whereas Sermorelin stimulates endogenous GH release by acting upstream at the pituitary. This preserves the hypothalamic–pituitary feedback loop and a more physiologic secretory rhythm.
Sermorelin has a molecular weight of 3,357.93 g/mol. Every vial is supplied at ≥99% purity, verified by HPLC, with a Certificate of Analysis included.
Keep lyophilized vials at -20°C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within approximately 14 days.
No. Sermorelin is sold strictly as a research compound for laboratory and in-vitro use only. It is not intended for human or animal consumption, diagnosis, or treatment.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
Clin Interv Aging
[2]Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency?
View source BioDrugs
[3]Sermorelin: A Review of Its Use in the Diagnosis and Treatment of Idiopathic Growth Hormone Deficiency
View source Endocr Rev
Human Growth Hormone and Human Aging
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.