● In Stock
Sermorelin
≥99% Purity | HPLC Verified
$100.00
PASSED
Sterility & Endotoxins
PASSED
Net Content & Purity
Purity:
≥99%
Store at
-20°C
Sermorelin is a high-purity research compound for research use only.
Additional product information will be available soon.
29
Amino Acids
GHRH(1–29) active fragment
3,357.93
Molecular Weight
g/mol (acetate salt)
GH↑
Stimulates Release
Endogenous & pulsatile
99%+
Purity Verified
HPLC tested, COA included
How Sermorelin Works
A synthetic growth hormone-releasing hormone analog (GHRH 1–29) that stimulates the pituitary to secrete the body's own growth hormone
GHRH-R
GHRH Receptor Agonism
Sermorelin binds growth hormone-releasing hormone receptors on anterior-pituitary somatotrophs, stimulating the synthesis and pulsatile release of endogenous growth hormone rather than supplying it exogenously.
- Activates pituitary somatotrophs
- Pulsatile GH release
- Endogenous secretion
GH → IGF-1
Downstream IGF-1 Signaling
Increased growth hormone drives hepatic production of insulin-like growth factor 1 (IGF-1), the principal mediator of GH's anabolic and metabolic effects on muscle, bone, connective tissue, and lipid metabolism.
- Hepatic IGF-1 synthesis
- Protein anabolism
- Lipolytic signaling
Feedback
Preserved Physiologic Rhythm
Because stimulation acts upstream at the pituitary, GH output remains subject to somatostatin and IGF-1 negative feedback, helping maintain a natural secretory rhythm instead of a fixed exogenous level.
- Somatostatin-regulated
- Negative feedback intact
- Natural pulsatility
Distinguishing Features
How a GHRH analog differs from exogenous growth hormone
Upstream
Stimulates, Not Replaces
Unlike recombinant HGH, which delivers growth hormone directly, Sermorelin prompts the pituitary to release its own GH — preserving the hypothalamic–pituitary axis and its regulatory checkpoints.
- Works upstream of GH
- HP axis preserved
- Self-limiting response
Half-Life
Short Plasma Half-Life
Sermorelin has a brief plasma half-life on the order of minutes, producing transient GH pulses that more closely resemble natural secretory bursts than the sustained elevation seen with exogenous GH.
- ~10–20 min half-life
- Transient GH pulses
- Mimics physiology
Sequence
GHRH(1–29) Active Fragment
Sermorelin corresponds to the first 29 amino acids of human GHRH — the shortest fully active N-terminal sequence — making it a well-characterized research probe of the somatotropic axis.
- 29-residue peptide
- Fully active fragment
- Well-characterized
Research Applications
Primary domains in the GHRH-analog literature
Endocrine
Growth Hormone Axis
Used as a research probe of pituitary GH secretory reserve; the GHRH stimulation test has historically been employed to assess somatotroph function.
Body Composition
Lean Mass & Adiposity
GH secretagogues are studied for their influence on lean body mass, fat mass, and metabolic rate in models of age- or disease-related GH decline.
Sleep & Recovery
Slow-Wave Sleep
Endogenous GH release is tightly coupled to slow-wave sleep, so GHRH analogs are studied to explore the link between the somatotropic axis and sleep architecture.
Aging Research
Somatopause
Age-related decline in GH and IGF-1 — termed somatopause — is modeled with GHRH analogs to investigate restoration of more youthful secretory patterns.
Safety Profile from Research
Observations reported in the research literature
✓Generally well tolerated in the research literature; reported effects are typically mild and transient.
✓Injection-site reactions — redness, swelling, or itching — are the most commonly reported local effects.
✓Transient flushing, headache, or an altered sense of taste have occasionally been reported.
✓By acting upstream at the pituitary, Sermorelin preserves feedback-regulated, pulsatile GH release rather than producing sustained supraphysiologic levels.
✓Its short plasma half-life limits prolonged growth hormone elevation.
✓Sold strictly for laboratory and in-vitro research use only — not for human or veterinary consumption.
| Compound Class | Growth hormone-releasing hormone (GHRH) analog |
| Research Name | Sermorelin (GHRH 1–29) |
| Sequence | N-terminal 29-amino-acid fragment of human GHRH |
| Target | GHRH receptor (pituitary somatotrophs) |
| Form | Lyophilized powder |
| Molecular Weight | 3,357.93 g/mol |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Half-Life | ~10–20 minutes (plasma) |
| Storage (lyophilized) | -20°C for long-term stability |
| Storage (reconstituted) | 2–8°C, use within 14 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
Frequently Asked Questions
Common questions about Sermorelin
Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH) — the shortest fully active fragment. It stimulates the pituitary to secrete the body's own growth hormone in a natural, pulsatile fashion.
Recombinant HGH supplies growth hormone directly, whereas Sermorelin stimulates endogenous GH release by acting upstream at the pituitary. This preserves the hypothalamic–pituitary feedback loop and a more physiologic secretory rhythm.
Sermorelin has a molecular weight of 3,357.93 g/mol. Every vial is supplied at ≥99% purity, verified by HPLC, with a Certificate of Analysis included.
Keep lyophilized vials at -20°C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within approximately 14 days.
No. Sermorelin is sold strictly as a research compound for laboratory and in-vitro use only. It is not intended for human or animal consumption, diagnosis, or treatment.
Sources & References
Clin Interv Aging
Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency?
2006
BioDrugs
Sermorelin: A Review of Its Use in the Diagnosis and Treatment of Idiopathic Growth Hormone Deficiency
1999
Published research on this compound is available through PubMed and other scientific databases.
Certificate of Analysis
| Analysis Date: | Available on request |
| Lot Number: | Batch-specific |
| Purity: | >99% (HPLC) |
Third-Party Testing
- ✓ Identity verification (Mass Spectrometry)
- ✓ Purity analysis (HPLC)
- ✓ Sterility testing
- ✓ Endotoxin screening
Storage Conditions
- Lyophilized: Store at -20°C, protected from light
- Reconstituted: Store at 2-8°C, use within 30 days
- Stability: 24 months from manufacture date when stored properly
Handling Guidelines
- Use sterile technique when reconstituting
- Allow vial to reach room temperature before opening
- Reconstitute with bacteriostatic water or sterile saline
- Avoid repeated freeze-thaw cycles
RESEARCH INSIGHTS
3D Structure
Sermorelin
This compound has been extensively studied in peer-reviewed literature. Eon Peptides provides this product exclusively for legitimate in-vitro research and analytical applications.
- • High-purity research compound
- • Full analytical documentation included
- • Third-party verification available
PRODUCT SPECIFICATIONS
LOT DATA
| Lot Number | Assigned on shipment |
| Verified Purity | >99% |
| Quantity | 5mg |
MOLECULAR DATA
| Molecular Formula | Available on request |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
