Sleep Architecture
Studied for effects on slow-wave sleep, sleep efficiency and onset latency in animal and human models.

Studied for deeper sleep, stress relief, and hormone balance
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DSIP stands for delta sleep-inducing peptide. It is nine amino acids long and was first isolated in 1977 from blood drawn during deep sleep. Studies have measured brain wave patterns, sleep timing, and stress hormone response. After nearly fifty years of research, no one has identified which receptor it binds. The mechanism is still an open question.
Naturally occurring nonapeptide neuropeptide (WAGGDASGE)
The pathways DSIP acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
DSIP has been reported to influence serotonin (5-HT), glutamate, dopamine and melatonin signaling — pathways tied to sleep onset and circadian timing.
Early studies associate DSIP with greater slow-wave (delta) sleep, shorter sleep onset and higher sleep efficiency, distinct from sedative-hypnotic mechanisms.
Investigated for adaptation of the stress (HPA) axis and for neuronal oxidative-stress endpoints in neurodegeneration and stroke models.
The main areas DSIP is being studied for — and the study-reported figures behind them.
Studied for effects on slow-wave sleep, sleep efficiency and onset latency in animal and human models.
Investigated for modulation of the HPA axis and stress-response regulation.
Explored for antioxidant/neuroprotective effects in models of neurodegeneration and ischemic injury.
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C₃₅H₄₈N₁₀O₁₅
Every batch of DSIP is sent to an accredited independent laboratory before it ships. Here is what we screen for.
| Also Known As | Delta Sleep-Inducing Peptide, Sleep-Promoting Peptide |
| Type | Nonapeptide neuropeptide |
| CAS Number | 62568-57-4 |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | 848.8 g/mol |
| Amino Acid Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Physical Appearance | White lyophilized powder |
| Purity | ≥99% (HPLC) |
| Content | 10 mg per vial |
| Appearance | White to off-white powder |
| Stability | 24 months from manufacture date when stored properly |
| Storage | Store at -20°C, protected from light |
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in the 1970s from the cerebral venous blood of rabbits in an induced sleep state, studied as an endogenous modulator of sleep and stress.
Yes. DSIP is an endogenous neuropeptide found in the brain, hypothalamus and other tissues, which is part of why it is of interest as a physiological sleep regulator.
Primarily sleep regulation, but also stress adaptation, neuroprotection, chronic-pain models and studies of opioid/alcohol withdrawal.
Supplied as a lyophilized powder; store at -20°C, protected from light and moisture. Research use only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.