Molecular data
| Molecular formula | C149H246N44O42S |
|---|---|
| Molecular weight | 3357.93 Da |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg |
| Sequence length | 29 residues |
| CAS / identifier | 86168-78-7 |
| Physical form | Lyophilized powder |
| Available sizes | 10mg |
How it works
GHRH Receptor Agonism
Sermorelin binds growth hormone-releasing hormone receptors on anterior-pituitary somatotrophs, stimulating the synthesis and pulsatile release of endogenous growth hormone rather than supplying it exogenously.
- Activates pituitary somatotrophs
- Pulsatile GH release
- Endogenous secretion
Downstream IGF-1 Signaling
Increased growth hormone drives hepatic production of insulin-like growth factor 1 (IGF-1), the principal mediator of GH's anabolic and metabolic effects on muscle, bone, connective tissue, and lipid metabolism.
- Hepatic IGF-1 synthesis
- Protein anabolism
- Lipolytic signaling
Preserved Physiologic Rhythm
Because stimulation acts upstream at the pituitary, GH output remains subject to somatostatin and IGF-1 negative feedback, helping maintain a natural secretory rhythm instead of a fixed exogenous level.
- Somatostatin-regulated
- Negative feedback intact
- Natural pulsatility
Stimulates, Not Replaces
Unlike recombinant HGH, which delivers growth hormone directly, Sermorelin prompts the pituitary to release its own GH — preserving the hypothalamic–pituitary axis and its regulatory checkpoints.
- Works upstream of GH
- HP axis preserved
- Self-limiting response
Short Plasma Half-Life
Sermorelin has a brief plasma half-life on the order of minutes, producing transient GH pulses that more closely resemble natural secretory bursts than the sustained elevation seen with exogenous GH.
- ~10–20 min half-life
- Transient GH pulses
- Mimics physiology
GHRH(1–29) Active Fragment
Sermorelin corresponds to the first 29 amino acids of human GHRH — the shortest fully active N-terminal sequence — making it a well-characterized research probe of the somatotropic axis.
- 29-residue peptide
- Fully active fragment
- Well-characterized
What the research shows
Growth Hormone Axis
Used as a research probe of pituitary GH secretory reserve; the GHRH stimulation test has historically been employed to assess somatotroph function.
GHRH stimulation literature
Lean Mass & Adiposity
GH secretagogues are studied for their influence on lean body mass, fat mass, and metabolic rate in models of age- or disease-related GH decline.
Body-composition research
Slow-Wave Sleep
Endogenous GH release is tightly coupled to slow-wave sleep, so GHRH analogs are studied to explore the link between the somatotropic axis and sleep architecture.
Sleep-axis research
Somatopause
Age-related decline in GH and IGF-1 — termed somatopause — is modeled with GHRH analogs to investigate restoration of more youthful secretory patterns.
Aging-axis research
Specification
| Compound Class | Growth hormone-releasing hormone (GHRH) analog |
|---|---|
| Research Name | Sermorelin (GHRH 1–29) |
| Sequence | N-terminal 29-amino-acid fragment of human GHRH |
| Target | GHRH receptor (pituitary somatotrophs) |
| Form | Lyophilized powder |
| Molecular Weight | 3,357.93 g/mol |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Half-Life | ~10–20 minutes (plasma) |
| Storage (lyophilized) | -20°C for long-term stability |
| Storage (reconstituted) | 2–8°C, use within 14 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
| Molecular Formula | Available on request |
| Appearance | White to off-white powder |
| Quantity | 5mg |
| Stability | 24 months from manufacture date when stored properly |
Frequently asked questions
What is Sermorelin?
Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH) — the shortest fully active fragment. It stimulates the pituitary to secrete the body's own growth hormone in a natural, pulsatile fashion.
How is Sermorelin different from HGH?
Recombinant HGH supplies growth hormone directly, whereas Sermorelin stimulates endogenous GH release by acting upstream at the pituitary. This preserves the hypothalamic–pituitary feedback loop and a more physiologic secretory rhythm.
What is the molecular weight and purity?
Sermorelin has a molecular weight of 3,357.93 g/mol. Every vial is supplied at ≥99% purity, verified by HPLC, with a Certificate of Analysis included.
How should it be stored?
Keep lyophilized vials at -20°C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within approximately 14 days.
Is this product for human use?
No. Sermorelin is sold strictly as a research compound for laboratory and in-vitro use only. It is not intended for human or animal consumption, diagnosis, or treatment.
Literature
- Clin Interv Aging Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency?
- BioDrugs Sermorelin: A Review of Its Use in the Diagnosis and Treatment of Idiopathic Growth Hormone Deficiency
- Endocr Rev Human Growth Hormone and Human Aging
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.