Intestinal Inflammation & Colitis
A landmark study showed PepT1-mediated uptake of KPV significantly reduced intestinal inflammation in DSS- and TNBS-induced models of colitis.
Dalmasso et al. 2008≥99% Purity
KPV
Inflammation Pathway Studies
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About this compound
KPV is a small anti-inflammatory peptide derived from the hormone α-MSH, researched for calming gut and skin inflammation and supporting healing.
α-MSH-derived tripeptide (α-MSH 11–13)
- Formula
- C16H31N5O4
- Molecular weight
- 342.43 g/mol
- Form
- Lyophilized powder
0+
Published Studies
Anti-inflammatory peptide research
0
Amino Acids
Lys-Pro-Val (α-MSH 11–13)
NF-κB
Pathway Target
Master inflammatory regulator
0
Research Areas
Intestinal Inflammation & Colitis · α-MSH Anti-Inflammatory Signaling · Epithelial Wound Healing & more
How It Works
How KPV works
The pathways KPV acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Inflammatory Pathway Suppression
NF-κB Inhibition
At nanomolar concentrations, KPV inhibits activation of the NF-κB and MAP-kinase inflammatory signaling pathways. By blunting NF-κB — a master regulator of inflammatory gene expression — KPV reduces secretion of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β.
- Inhibits NF-κB and MAP-kinase signaling at nanomolar levels
- Reduces TNF-α, IL-6, IL-1β and other pro-inflammatory cytokines
- Suppresses inflammatory output rather than boosting anti-inflammatory cytokines
Cellular Transport & Action
PepT1-Mediated Uptake
Research shows KPV is taken up by cells via the PepT1 di/tripeptide transporter, which is expressed on immune cells and intestinal epithelial cells. This transporter-mediated uptake allows KPV to act intracellularly on inflammatory signaling.
- Enters cells through the PepT1 peptide transporter
- PepT1 is expressed on immune and intestinal epithelial cells
- Enables intracellular modulation of inflammatory pathways
Melanocortin Fragment
α-MSH-Derived Activity
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH 11–13). Research indicates most of α-MSH's anti-inflammatory activity can be attributed to this fragment, which also shows antimicrobial activity in published studies.
- C-terminal tripeptide of the melanocortin peptide α-MSH
- Carries much of α-MSH's anti-inflammatory activity
- Antimicrobial effects reported against S. aureus and C. albicans
Uses & Applications
What KPV is researched for
The main areas KPV is being studied for — and the study-reported figures behind them.
α-MSH Anti-Inflammatory Signaling
KPV is studied as the C-terminal tripeptide that carries much of α-MSH's anti-inflammatory and immunomodulating activity.
Brzoska et al.Epithelial Wound Healing
In a rabbit corneal model, topical KPV produced complete re-epithelialization by 60 hours, with a mechanism that may involve nitric-oxide signaling.
Bonfiglio et al. 2006Antimicrobial Activity
KPV shows antimicrobial effects against Staphylococcus aureus and Candida albicans across a broad concentration range in published research.
Cutuli et al. 2000Molecular Structure
The KPV molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C16H31N5O4
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of KPV is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Chemical Name | KPV (Lys-Pro-Val) |
| Sequence | L-Lysyl-L-Prolyl-L-Valine (α-MSH 11–13) |
| Molecular Weight | 342.43 g/mol |
| Molecular Formula | C₁₆H₃₁N₅O₄ |
| Content | 10 mg per vial |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (Lyophilized) | -20°C for long-term stability |
| Storage (Reconstituted) | 2–8°C, use within 14 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
FAQ
Common questions about KPV
KPV is a tripeptide composed of lysine, proline, and valine. It is the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH 11–13), and research indicates this short fragment carries much of α-MSH's anti-inflammatory and immunomodulating activity.
At nanomolar concentrations, KPV inhibits the NF-κB and MAP-kinase inflammatory signaling pathways. NF-κB is a master regulator of inflammatory gene expression, so suppressing it lowers production of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β in research models.
PepT1 is a di/tripeptide transporter expressed on immune cells and intestinal epithelial cells. Research shows KPV enters cells through PepT1, which allows it to act intracellularly on inflammatory signaling — a mechanism considered central to its effects in intestinal-inflammation models.
In a landmark Gastroenterology study, PepT1-mediated uptake of KPV significantly reduced intestinal inflammation in DSS- and TNBS-induced mouse models of colitis, with decreased expression of pro-inflammatory cytokines including IL-1β, IL-6, IL-12, TNF-α and IFN-γ.
No. Despite roughly two decades of preclinical research across multiple organ systems, KPV has not completed human clinical trials. Research-grade KPV sold here is intended strictly for in vitro laboratory research and is not for human or veterinary use.
Lyophilized KPV should be stored at -20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, it should be kept at 2–8°C and used within approximately 14 days to preserve peptide integrity.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
PUBMED
[2]PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
View source PMC
[3]α-MSH Related Peptides: A New Class of Anti-Inflammatory and Immunomodulating Drugs
View source PUBMED
[4]Effects of the COOH-Terminal Tripeptide α-MSH(11–13) on Corneal Epithelial Wound Healing: Role of Nitric Oxide
View source PUBMED
Antimicrobial Effects of Alpha-MSH Peptides
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.