Cellular Senescence
Studied in cell-culture and rodent models for markers of replicative senescence and cellular lifespan.
Khavinson et al. 2003≥99% Purity
Epithalon
Telomere Lengthening Studies
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About this compound
Epithalon is a synthetic version of a natural pineal-gland peptide. It's best known in longevity research for activating telomerase — the enzyme that maintains the protective caps on our DNA — and for supporting healthy sleep and aging.
Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
- Formula
- C14H22N4O9
- Molecular weight
- 390.35 g/mol
- Form
- Lyophilized Powder
- CAS / ID
- 307297-39-8
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Published Studies
Preclinical & in-vitro papers
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Amino Acid Sequence
Ala-Glu-Asp-Gly tetrapeptide
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Telomere Elongation
Cultured human fibroblasts
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Research Areas
Cellular Senescence · Circadian & Pineal · Antioxidant Defense & more
How It Works
How Epithalon works
The pathways Epithalon acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Telomerase Activation & Telomere Biology
Telomerase
In cultured human somatic cells, Epithalon has been reported to induce expression of the telomerase catalytic subunit (hTERT) and elongate telomeres, extending the proliferative capacity of the cultures in preclinical models.
- Induction of hTERT expression in vitro
- Telomere elongation in cultured fibroblasts
- Extended proliferative lifespan of cell cultures
Pineal Peptide Signaling
Pineal / Circadian
Modeled on the pineal gland peptide epithalamin, Epithalon has been studied for its influence on melatonin secretion rhythm and circadian regulation in rodent models of aging.
- Based on the natural pineal peptide epithalamin
- Studied for melatonin secretion rhythm
- Circadian regulation in animal models
Chromatin & Antioxidant Regulation
Gene Expression
Preclinical work reports that Epithalon can interact with DNA and modulate expression of genes associated with cellular senescence and antioxidant defense in animal tissue.
- Proposed peptide–DNA interaction
- Modulation of senescence-associated genes
- Antioxidant enzyme expression in vitro
Uses & Applications
What Epithalon is researched for
The main areas Epithalon is being studied for — and the study-reported figures behind them.
Circadian & Pineal
Investigated for effects on melatonin rhythm and age-related changes in pineal function in animal models.
Anisimov et al. 2003Antioxidant Defense
Preclinical reports of reduced lipid peroxidation and modulation of antioxidant enzymes in aged animal tissue.
Khavinson 2002Age-Model Research
Used as a reference tetrapeptide in rodent studies of lifespan, tumour incidence, and physiological aging markers.
Anisimov & Khavinson 2010Molecular Structure
The Epithalon molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C14H22N4O9
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of Epithalon is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Strength | 50mg |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
| Verified Purity | >99% |
| Quantity | 5mg |
FAQ
Common questions about Epithalon
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a peptide isolated from the pineal gland. It has been studied primarily in gerontology research for telomerase activation and pineal/circadian biology in cell-culture and animal models.
No. Epithalon is not approved by the FDA or any regulatory agency for human use, and it is not a drug, supplement, or therapeutic product. It is supplied strictly as a reference compound for in-vitro laboratory research.
Store the lyophilized powder at −20°C or colder, protected from light. After reconstitution with bacteriostatic water, keep refrigerated at 2–8°C and use within the period indicated on the Certificate of Analysis. This is storage guidance for the researcher, not a shipping requirement.
Each lot is ≥99% pure by HPLC with identity confirmed by mass spectrometry, and ships with a third-party Certificate of Analysis documenting purity, net peptide content, and endotoxin screening.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
PubMed
[2]Peptide promotes overcoming of the division limit in human somatic cell
View source PubMed
[3]Effect of Epitalon on biomarkers of aging, life span and spontaneous tumour incidence in female CBA mice
View source PubMed
[4]Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
View source PubMed
Pineal peptides and aging: gerontological research review
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.