Molecular data
| Molecular formula | C14H22N4O9 |
|---|---|
| Molecular weight | 390.35 Da |
| Sequence | Ala-Glu-Asp-Gly |
| Sequence length | 4 residues |
| CAS / identifier | 307297-39-8 |
| Physical form | Lyophilized Powder |
| Available sizes | 50mg |
How it works
Telomerase Activation & Telomere Biology
In cultured human somatic cells, Epithalon has been reported to induce expression of the telomerase catalytic subunit (hTERT) and elongate telomeres, extending the proliferative capacity of the cultures in preclinical models.
- Induction of hTERT expression in vitro
- Telomere elongation in cultured fibroblasts
- Extended proliferative lifespan of cell cultures
Pineal Peptide Signaling
Modeled on the pineal gland peptide epithalamin, Epithalon has been studied for its influence on melatonin secretion rhythm and circadian regulation in rodent models of aging.
- Based on the natural pineal peptide epithalamin
- Studied for melatonin secretion rhythm
- Circadian regulation in animal models
Chromatin & Antioxidant Regulation
Preclinical work reports that Epithalon can interact with DNA and modulate expression of genes associated with cellular senescence and antioxidant defense in animal tissue.
- Proposed peptide–DNA interaction
- Modulation of senescence-associated genes
- Antioxidant enzyme expression in vitro
What the research shows
Cellular Senescence
Studied in cell-culture and rodent models for markers of replicative senescence and cellular lifespan.
Khavinson et al. 2003
Circadian & Pineal
Investigated for effects on melatonin rhythm and age-related changes in pineal function in animal models.
Anisimov et al. 2003
Antioxidant Defense
Preclinical reports of reduced lipid peroxidation and modulation of antioxidant enzymes in aged animal tissue.
Khavinson 2002
Age-Model Research
Used as a reference tetrapeptide in rodent studies of lifespan, tumour incidence, and physiological aging markers.
Anisimov & Khavinson 2010
Specification
| Strength | 50mg |
|---|---|
| molecular_formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
| Molecular Formula | Available on request |
| Verified Purity | >99% |
| Quantity | 5mg |
| Lot Number | Assigned on shipment |
Frequently asked questions
What is Epithalon?
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a peptide isolated from the pineal gland. It has been studied primarily in gerontology research for telomerase activation and pineal/circadian biology in cell-culture and animal models.
Is Epithalon FDA approved?
No. Epithalon is not approved by the FDA or any regulatory agency for human use, and it is not a drug, supplement, or therapeutic product. It is supplied strictly as a reference compound for in-vitro laboratory research.
How should Epithalon be stored?
Store the lyophilized powder at −20°C or colder, protected from light. After reconstitution with bacteriostatic water, keep refrigerated at 2–8°C and use within the period indicated on the Certificate of Analysis. This is storage guidance for the researcher, not a shipping requirement.
What purity is this Epithalon?
Each lot is ≥99% pure by HPLC with identity confirmed by mass spectrometry, and ships with a third-party Certificate of Analysis documenting purity, net peptide content, and endotoxin screening.
Literature
- PubMed Peptide promotes overcoming of the division limit in human somatic cell
- PubMed Effect of Epitalon on biomarkers of aging, life span and spontaneous tumour incidence in female CBA mice
- PubMed Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
- PubMed Pineal peptides and aging: gerontological research review
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.