Wound Healing
Accelerates dermal wound closure, reduces scarring, and promotes organized collagen deposition in preclinical wound models.
Malinda et al. 2007≥99% Purity
TB-500
Cell Migration Studies
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PASSEDSterility & Endotoxins
PASSEDNet Content & Purity
Researchers also added
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About this compound
TB-500 is the active fragment of Thymosin Beta-4, researched for accelerating healing, flexibility, and recovery by helping cells migrate and rebuild tissue.
43-amino acid fragment of Thymosin Beta-4 (Tβ4) active region
- Formula
- C212H350N56O78S
- Molecular weight
- 4963.44 g/mol
- Form
- Lyophilized Powder
0%
Faster Healing
Re-epithelialization vs controls
0+
Published Studies
Preclinical research papers
0
Research Areas
Wound Healing · Cardiac Repair · Corneal Healing & more
How It Works
How TB-500 works
The pathways TB-500 acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Cell Migration & Motility
Actin Regulation
TB-500 binds G-actin monomers and promotes actin polymerization, enabling cells to migrate to injury sites. This is the primary mechanism driving its tissue repair properties in preclinical models.
- Sequesters G-actin to regulate polymerization
- Promotes cell migration to injury sites
- Enhances cytoskeletal remodeling
Cardiac Repair Signaling
Cardiac
In cardiac research, TB-500 activates integrin-linked kinase (ILK) and promotes cardiac progenitor cell migration. Phase II clinical trials have been conducted for cardiac repair applications.
- Activates integrin-linked kinase (ILK)
- Promotes cardiac progenitor cell migration
- Phase II clinical trial data available
Inflammation Modulation
Anti-Inflammatory
TB-500 downregulates pro-inflammatory cytokines and modulates macrophage activity, shifting the immune response from inflammatory to regenerative in preclinical wound models.
- Reduces pro-inflammatory cytokines
- Modulates macrophage polarization
- Supports anti-fibrotic tissue remodeling
Uses & Applications
What TB-500 is researched for
The main areas TB-500 is being studied for — and the study-reported figures behind them.
Cardiac Repair
Promotes cardiac cell migration via ILK activation. Phase II clinical trials conducted for post-myocardial infarction repair.
Bock-Marquette et al. 2004Corneal Healing
Promotes corneal epithelial wound healing and reduces inflammation in ocular surface damage models.
Sosne et al. 2018Soft Tissue Repair
Enhances muscle, tendon, and ligament repair through actin-mediated cell migration and reduced fibrotic scarring.
Goldstein et al. 2010Molecular Structure
The TB-500 molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C212H350N56O78S
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of TB-500 is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Active Fragment | Thymosin Beta-4 (Tβ4) active region |
| Amino Acids | 43-amino acid peptide |
| Molecular Weight | 4,963 Da |
| Form | Lyophilized powder (10mg) |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage (Lyophilized) | -20°C for long-term stability |
| Storage (Reconstituted) | 2–8°C, use within 14-21 days |
| Solubility | Bacteriostatic water for reconstitution |
| COA | Included with every order |
FAQ
Common questions about TB-500
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a 43-amino acid protein naturally found in all nucleated cells. It plays a central role in cell migration, differentiation, and tissue repair through its interaction with the actin cytoskeleton.
TB-500 contains the active fragment of the full Thymosin Beta-4 protein. While Tβ4 is the complete 43-amino acid sequence, TB-500 focuses on the region responsible for actin binding and cell migration properties. Both share the same core mechanism of action.
Yes — Thymosin Beta-4 (RegeneRx Biopharmaceuticals) has been studied in Phase II clinical trials for cardiac repair after myocardial infarction, as well as corneal wound healing. These trials showed acceptable safety profiles. TB-500 as sold for research has not itself been in FDA-approved trials.
TB-500 is studied in preclinical models for wound healing, cardiac tissue repair, corneal healing, muscle/tendon recovery, and anti-inflammatory applications. Its primary mechanism — promoting cell migration via actin regulation — is relevant across multiple tissue types.
Store lyophilized TB-500 at -20°C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 14-21 days. Avoid repeated freeze-thaw cycles.
No. TB-500 is not FDA approved for any indication. It is available exclusively for in vitro laboratory research. While the parent molecule (Thymosin Beta-4) has been in clinical trials, TB-500 itself has not received regulatory approval.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
PubMed
[2]Thymosin beta-4 promotes dermal healing
View source PubMed
[3]Thymosin beta 4 activates integrin-linked kinase and promotes cardiac cell migration
View source PubMed
[4]Thymosin beta-4 and the eye: Current concepts and therapeutic potential
View source PubMed
The role of thymosin beta-4 in tissue repair and remodeling
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.