Preclinical study index · Research use only

SS-31: preclinical and in-vitro studies

8 published studies on SS-31, limited by rule to animal models and cell-based (in vitro) work indexed in PubMed, spanning 2022 to 2026 across 6 journals. Human trials, case reports and literature overviews are excluded. Titles appear as published; each links to its PubMed record and, where one is registered, its DOI.

  • 8studies listed
  • 8with an animal model
  • 5with in-vitro work
  • 2022 to 2026publication years
  • 6journals

Evidence table

#YearStudyJournalModelRecord
1 2026 Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat ModelPMID 42290373 Circulation. Heart failure Rats model and in vitro PubMed · DOI
2 2026 SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarizationPMID 41136322 Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Rats and Mice model and in vitro PubMed · DOI
3 2025 SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targetingPMID 39848110 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Rats model and in vitro PubMed · DOI
4 2025 Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screeningPMID 40169521 GeroScience Mice model and in vitro PubMed · DOI
5 2023 Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shockPMID 36934127 Scientific reports Swine model PubMed · DOI
6 2023 Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilizationPMID 36609266 Journal of neuroinflammation Mice model PubMed · DOI
7 2023 Intermittent treatment with elamipretide preserves exercise tolerance in aged female micePMID 36840897 GeroScience Mice model and in vitro PubMed · DOI
8 2022 Elamipretide effects on the skeletal muscle phosphoproteome in aged female micePMID 36322234 GeroScience Mice model PubMed · DOI

Studies by model

  • In vitro · 5 studies
  • Mice · 5 studies
  • Rats · 3 studies
  • Swine · 1 study

What this index does not include

Human research of any kind: publications typed by PubMed as human studies or case reports, and papers whose titles or abstracts describe human subjects, are removed by rule. Literature overviews, meta-analyses, editorials and letters are removed because they summarise rather than report. Papers whose titles contain usage or outcome language that would not pass this site's research-use-only copy rules are dropped rather than reworded, since a published title is a fact that cannot be edited.

Nothing on this page is a statement about effects in humans, a recommendation, or a description of the material supplied. SS-31 is supplied for laboratory research only.

How this index is built

PubMed is searched on the names the literature uses for SS-31 (SS-31, elamipretide, Bendavia, MTP-131), restricted to records indexed to an animal or cell model, in English, with an abstract. Clinical publication types, human-subject language and overview-type publications are excluded. The compound must be named in the title. Candidates are ranked by title match, indexing quality and year; the shortlist is read by a person before it is published, and a small blocklist holds records rejected on that read. The list was resolved on 2026-10-12 and is re-run deliberately, never on a timer.

Questions

Are there human studies of SS-31 in this index?

No, by design. This index lists animal and cell-based research only. Publications typed as human studies, case reports or literature overviews, and papers whose titles or abstracts describe human subjects, are excluded by rule before anything is listed. Eon Peptides supplies SS-31 for laboratory research and makes no statement about use in humans.

Which research models appear most often for SS-31?

Across the 8 studies listed: In vitro (5), Mice (5), Rats (3), Swine (1). A model label is taken from PubMed's indexing of each paper, or from its title and abstract when the record is too new to be indexed. It describes the study, not the material.

How are the studies selected?

A PubMed search on the published names of the compound (SS-31, elamipretide, Bendavia, MTP-131) is filtered to records indexed to an animal or cell model, with clinical publication types, human-subject language and overview-type publications removed. The compound must be named in the title. Remaining records are ranked by title match, indexing quality and year, and the top 8 are listed after a manual read. The list was resolved against PubMed on 2026-10-12.

Does a listing here say anything about the SS-31 Eon Peptides sells?

No. A listing records that a study was published and what it examined. It says nothing about the properties, quality or intended use of any material. What Eon Peptides does document about its own SS-31 is on the certificate pages: lot-level identity and purity results from independent laboratories.

Related pages

For research use only. Not for human or veterinary use. Preclinical and in-vitro studies only: animal models and cell-based work indexed in PubMed. Human trials, case reports and literature overviews are excluded by rule.