Preclinical study index · Research use only

GHK-Cu: preclinical and in-vitro studies

8 published studies on GHK-Cu, limited by rule to animal models and cell-based (in vitro) work indexed in PubMed, spanning 2016 to 2026 across 8 journals. Human trials, case reports and literature overviews are excluded. Titles appear as published; each links to its PubMed record and, where one is registered, its DOI.

  • 8studies listed
  • 7with an animal model
  • 6with in-vitro work
  • 2016 to 2026publication years
  • 8journals

Evidence table

#YearStudyJournalModelRecord
1 2026 The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathwaysPMID 42084774 Biogerontology C. elegans model and in vitro PubMed · DOI
2 2020 Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathwaysPMID 31809714 Life sciences Mice model PubMed · DOI
3 2020 Hydrogels based on low-methoxyl amidated citrus pectin and flaxseed gum formulated with tripeptide glycyl-l-histidyl-l-lysine improve the healing of experimental cutting wounds in ratsPMID 33031852 International journal of biological macromolecules Rats model PubMed · DOI
4 2024 Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitroPMID 38599632 Metallomics : integrated biometal science Animal model and in vitro PubMed · DOI
5 2019 Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivityPMID 31500015 Materials science & engineering. C, Materials for biological applications Mice model and in vitro PubMed · DOI
6 2023 Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin testsPMID 37062921 Journal of cosmetic dermatology In vitro PubMed · DOI
7 2017 GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesisPMID 28370978 Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Mice model and in vitro PubMed · DOI
8 2016 The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in micePMID 27517151 Oncotarget Mice model and in vitro PubMed · DOI

Studies by model

  • In vitro · 6 studies
  • Mice · 4 studies
  • C. elegans · 1 study
  • Rats · 1 study
  • Animal model (species not indexed) · 1 study

What this index does not include

Human research of any kind: publications typed by PubMed as human studies or case reports, and papers whose titles or abstracts describe human subjects, are removed by rule. Literature overviews, meta-analyses, editorials and letters are removed because they summarise rather than report. Papers whose titles contain usage or outcome language that would not pass this site's research-use-only copy rules are dropped rather than reworded, since a published title is a fact that cannot be edited.

Nothing on this page is a statement about effects in humans, a recommendation, or a description of the material supplied. GHK-Cu is supplied for laboratory research only.

How this index is built

PubMed is searched on the names the literature uses for GHK-Cu (GHK-Cu, glycyl-L-histidyl-L-lysine, copper tripeptide), restricted to records indexed to an animal or cell model, in English, with an abstract. Clinical publication types, human-subject language and overview-type publications are excluded. The compound must be named in the title. Candidates are ranked by title match, indexing quality and year; the shortlist is read by a person before it is published, and a small blocklist holds records rejected on that read. The list was resolved on 2026-10-12 and is re-run deliberately, never on a timer.

Questions

Are there human studies of GHK-Cu in this index?

No, by design. This index lists animal and cell-based research only. Publications typed as human studies, case reports or literature overviews, and papers whose titles or abstracts describe human subjects, are excluded by rule before anything is listed. Eon Peptides supplies GHK-Cu for laboratory research and makes no statement about use in humans.

Which research models appear most often for GHK-Cu?

Across the 8 studies listed: In vitro (6), Mice (4), C. elegans (1), Rats (1), Animal model (species not indexed) (1). A model label is taken from PubMed's indexing of each paper, or from its title and abstract when the record is too new to be indexed. It describes the study, not the material.

How are the studies selected?

A PubMed search on the published names of the compound (GHK-Cu, glycyl-L-histidyl-L-lysine, copper tripeptide) is filtered to records indexed to an animal or cell model, with clinical publication types, human-subject language and overview-type publications removed. The compound must be named in the title. Remaining records are ranked by title match, indexing quality and year, and the top 8 are listed after a manual read. The list was resolved against PubMed on 2026-10-12.

Does a listing here say anything about the GHK-Cu Eon Peptides sells?

No. A listing records that a study was published and what it examined. It says nothing about the properties, quality or intended use of any material. What Eon Peptides does document about its own GHK-Cu is on the certificate pages: lot-level identity and purity results from independent laboratories.

Related pages

For research use only. Not for human or veterinary use. Preclinical and in-vitro studies only: animal models and cell-based work indexed in PubMed. Human trials, case reports and literature overviews are excluded by rule.