SS-31 vs MOTS-c
SS-31 is a mitochondria-targeted aromatic-cationic tetrapeptide (cardiolipin-binding). MOTS-c is a mitochondrial-derived 16-amino acid peptide. They are different materials with different identities and different research literatures; the table below sets the two identities side by side, the sections after it summarise what each is studied for, and the certificate rows show how each has tested.
SS-31 and MOTS-c side by side
| Field | SS-31 | MOTS-c |
|---|---|---|
| Catalogue name | SS-31 | MOTS-c |
| Type | Single peptide | Single peptide |
| Class | Mitochondria-targeted aromatic-cationic tetrapeptide (cardiolipin-binding) | Mitochondrial-derived 16-amino acid peptide |
| Components | Single compound | Single compound |
| Molecular formula | C32H49N9O5 | C101H152N28O25S2 |
| Molecular weight | 638.8 Da | 2174.64 Da |
| Sequence length | 4 residues | 16 residues |
| CAS or identifier | Elamipretide, MTP-131, Bendavia | Not assigned |
| Form supplied | Lyophilized powder | Lyophilized powder |
| Sizes | 10mg, 30mg, 50mg | 10mg, 30mg, 50mg |
| Price from | $60 | $60 |
| Documented HPLC results | 6 (99.63 to 99.89%) | 8 (99.52 to 99.90%) |
| Testing laboratories | Accurate Test Labs, Freedom Diagnostics | Freedom Diagnostics, Accurate Test Labs |
Identity fields come from the catalogue entry for each compound. Certificate counts are documented third-party HPLC results with a published certificate; image-only documents are excluded from the counts.
What the research literature describes
SS-31
- Inner Mitochondrial Membrane Stabilization Cardiolipin Binding
- Mitochondrial Reactive Oxygen Species Reduction ROS Scavenging
- Bioenergetic Function ATP Synthesis
MOTS-c
- AMP-Activated Protein Kinase Signaling AMPK Activation
- Mitochondria-to-Nucleus Retrograde Signaling mtDNA Origin
- Metabolic Homeostasis & Exercise Signaling Exercise Mimetic
What each is studied for
SS-31
- Heart Failure Cardiology Research
- Reperfusion Injury Ischemia Models
- Mitochondrial Aging Aging Biology
- Renal Models Nephrology Research
MOTS-c
- Insulin Sensitivity Models Metabolic Research
- Age-Related Metabolic Decline Aging Biology
- Exercise Mimicry Exercise Biology
- mtDNA Variation & Ageing Cohorts Population Genetics
Headings name the mechanisms and research applications described for each compound; the full text of each sits on the compound monograph linked below. They summarise findings reported in preclinical models. They describe what has been studied, not outcomes in people or animals outside the laboratory.
Catalogue, monographs and certificates
- SS-31 in the catalogueSizes, price and current certificate
- SS-31 monographMolecular data and mechanisms studied
- SS-31 lab resultsEvery third-party certificate
- MOTS-c in the catalogueSizes, price and current certificate
- MOTS-c lab resultsEvery third-party certificate
- All comparisonsEvery pair in the library
What is the difference between SS-31 and MOTS-c?
SS-31 is a mitochondria-targeted aromatic-cationic tetrapeptide (cardiolipin-binding); MOTS-c is a mitochondrial-derived 16-amino acid peptide. SS-31 has 4 residues and MOTS-c has 16. Their molecular identities, the models they have been studied in and their certificate records are all listed on this page.
Are SS-31 and MOTS-c sold together?
No. Eon Peptides lists them as separate catalogue items, each with its own sizes and its own certificates.
How has each tested?
SS-31: 6 documented third-party HPLC results from 99.63% to 99.89%. MOTS-c: 8 documented results from 99.52% to 99.90%. Every certificate is published and linked from each compound's lab results page.
Which one should a research project use?
That depends on the pathway and model under study, which is a scientific question this page does not answer. What it does is put the identities, the described mechanisms and the analytical records side by side so the choice can be made on documented facts. Both materials are for laboratory research use only.
For research use only. Not for human or veterinary use. Nothing on this page describes or recommends use in people or animals.