T-Cell Research
Used to study thymic-dependent T-lymphocyte maturation and immune reconstitution in immunosuppressed animal models.
Garaci et al. 2007≥99% Purity
Thymosin Alpha-1
Immune Response Studies
$85.00$42.50/vial with BOGO
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PASSEDSterility & Endotoxins
PASSEDNet Content & Purity
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About this compound
Thymosin Alpha-1 is a natural thymic peptide and one of the most studied immune modulators — researched for strengthening and rebalancing the immune system's response to infection, inflammation, and disease.
28-amino-acid thymic peptide
- Formula
- C129H215N33O55
- Molecular weight
- 3108.29 g/mol
- Form
- Lyophilized Powder
- CAS / ID
- 62304-98-7
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Amino Acid Sequence
Acetylated thymic peptide
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Published Studies
Immunology literature
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NK-Cell Activity
In-vitro immune models
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Research Areas
T-Cell Research · Viral-Response Models · Tumour-Immunity Models & more
How It Works
How Thymosin Alpha-1 works
The pathways Thymosin Alpha-1 acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Thymic Immune Modulation
T-Cell Maturation
Thymosin Alpha-1 promotes the maturation and differentiation of T-lymphocytes and modulates the balance of T-cell subsets in preclinical immunology models.
- Promotes T-cell differentiation
- Modulates CD4+/CD8+ balance
- Restores lymphocyte counts in immunosuppressed models
Toll-Like Receptor Activation
TLR Signaling
Research indicates Tα1 signals through Toll-like receptors (notably TLR2 and TLR9) on dendritic cells and monocytes, influencing innate-immune activation and cytokine expression.
- Engages TLR2 / TLR9 pathways
- Dendritic-cell maturation
- Modulates cytokine profiles
NK & Th1 Cytokine Modulation
Cytokine / NK
In-vitro and animal studies report enhanced natural-killer-cell activity and a shift toward a Th1 cytokine profile (IFN-γ, IL-2), supporting antiviral and antitumour immune-response research.
- Increased NK-cell activity
- Th1 cytokine shift (IFN-γ, IL-2)
- Studied in viral and tumour models
Uses & Applications
What Thymosin Alpha-1 is researched for
The main areas Thymosin Alpha-1 is being studied for — and the study-reported figures behind them.
Viral-Response Models
Investigated in hepatitis and other viral models for its influence on innate and adaptive antiviral immunity.
Loggi et al. 2020Tumour-Immunity Models
Studied as an immune adjuvant in preclinical tumour models for enhancement of NK and cytotoxic T-cell responses.
Costantini et al. 2019Cytokine Regulation
Examined for modulation of inflammatory cytokine networks and dendritic-cell function in vitro.
Romani et al. 2012Molecular Structure
The Thymosin Alpha-1 molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C129H215N33O55
Third-Party Verified
Independently tested. Verifiably pure.
Every batch of Thymosin Alpha-1 is sent to an accredited independent laboratory before it ships. Here is what we screen for.
- HPLC Purity AnalysisConfirms the peptide is ≥99% pure
- Mass SpectrometryVerifies the exact molecular identity
- Heavy Metals ScreeningLead, arsenic, cadmium & mercury — Pass
- Endotoxins (LAL)Bacterial endotoxin levels — Pass
- Sterility TestingNo microbial contamination — Pass
- Net Peptide ContentActual peptide mass per vial verified
Certificate of Analysis · Freedom DiagnosticPASS
- HPLC Purity
- ≥99%
- Identity
- Mass-spec confirmed
- Endotoxin (LAL)
- Pass
- Net content
- Verified
Compound Information
Full specification
| Strength | 10mg |
| Molecular Formula | C129H215N33O55 |
| Molecular Weight | 3108.29 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Verified Purity | >99% |
| Quantity | 10mg |
| Appearance | White to off-white powder |
| Stability | 24 months from manufacture date when stored properly |
| Lyophilized Storage | Store at -20°C, protected from light |
| Reconstituted Storage | Store at 2-8°C, use within 30 days |
FAQ
Common questions about Thymosin Alpha-1
Thymosin Alpha-1 (Tα1) is an acetylated 28-amino-acid peptide originally isolated from thymic tissue (thymosin fraction 5). It is a well-characterized immunomodulator studied for its effects on T-cell maturation, Toll-like-receptor signaling, and innate/adaptive immune balance in cell-culture and animal models.
No. Thymosin Alpha-1 is not approved by the FDA for any use in the United States. A synthetic form (thymalfasin) is approved as an immunomodulator in a number of other countries, but this product is supplied strictly as a reference compound for in-vitro laboratory research.
Store the lyophilized powder at −20°C, protected from light; it is stable for approximately 24 months from manufacture. After reconstitution, keep refrigerated at 2–8°C and use within 30 days. This is storage guidance for the researcher, not a shipping requirement.
Each lot is ≥99% pure by HPLC with identity confirmed by mass spectrometry and ships with third-party analytical documentation of purity, net peptide content, and endotoxin screening.
Published Literature
Cited Sources
Peer-reviewed literature
Independent published research indexed from PubMed and peer-reviewed journals — not Eon Peptides claims.
[1]
PubMed
[2]Thymosin alpha 1: an endogenous regulator of inflammation, immunity, and tolerance
View source PubMed
[3]Thymosin alpha 1 activates dendritic cells via Toll-like receptor 9 signaling
View source PubMed
[4]Thymosin alpha 1: a comprehensive review of the literature
View source PubMed
Thymosin alpha 1 in the treatment of viral infections
View source For Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.