Preclinical study index · Research use only

MOTS-c: preclinical and in-vitro studies

8 published studies on MOTS-c, limited by rule to animal models and cell-based (in vitro) work indexed in PubMed, spanning 2025 to 2026 across 6 journals. Human trials, case reports and literature overviews are excluded. Titles appear as published; each links to its PubMed record and, where one is registered, its DOI.

  • 8studies listed
  • 8with an animal model
  • 7with in-vitro work
  • 2025 to 2026publication years
  • 6journals

Evidence table

#YearStudyJournalModelRecord
1 2026 Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathwayPMID 41802484 European journal of pharmacology Mice model and in vitro PubMed · DOI
2 2026 MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interactionPMID 42128272 Life sciences Rats and Mice model and in vitro PubMed · DOI
3 2026 LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protectionPMID 42142418 Redox biology Mice model and in vitro PubMed · DOI
4 2026 MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantationPMID 42153537 Autophagy Mice model and in vitro PubMed · DOI
5 2025 MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent MechanismPMID 41043625 Free radical biology & medicine Mice model and in vitro PubMed · DOI
6 2025 MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genesPMID 40403491 Redox biology Rats model PubMed · DOI
7 2025 Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretionPMID 39706498 Free radical biology & medicine Mice model and in vitro PubMed · DOI
8 2025 MOTS-c Impact on Muscle Cell Differentiation and Metabolism Across Fiber TypesPMID 39876762 Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Rats and Mice model and in vitro PubMed · DOI

Studies by model

  • Mice · 7 studies
  • In vitro · 7 studies
  • Rats · 3 studies

What this index does not include

Human research of any kind: publications typed by PubMed as human studies or case reports, and papers whose titles or abstracts describe human subjects, are removed by rule. Literature overviews, meta-analyses, editorials and letters are removed because they summarise rather than report. Papers whose titles contain usage or outcome language that would not pass this site's research-use-only copy rules are dropped rather than reworded, since a published title is a fact that cannot be edited.

Nothing on this page is a statement about effects in humans, a recommendation, or a description of the material supplied. MOTS-c is supplied for laboratory research only.

How this index is built

PubMed is searched on the names the literature uses for MOTS-c (MOTS-c), restricted to records indexed to an animal or cell model, in English, with an abstract. Clinical publication types, human-subject language and overview-type publications are excluded. The compound must be named in the title. Candidates are ranked by title match, indexing quality and year; the shortlist is read by a person before it is published, and a small blocklist holds records rejected on that read. The list was resolved on 2026-10-12 and is re-run deliberately, never on a timer.

Questions

Are there human studies of MOTS-c in this index?

No, by design. This index lists animal and cell-based research only. Publications typed as human studies, case reports or literature overviews, and papers whose titles or abstracts describe human subjects, are excluded by rule before anything is listed. Eon Peptides supplies MOTS-c for laboratory research and makes no statement about use in humans.

Which research models appear most often for MOTS-c?

Across the 8 studies listed: Mice (7), In vitro (7), Rats (3). A model label is taken from PubMed's indexing of each paper, or from its title and abstract when the record is too new to be indexed. It describes the study, not the material.

How are the studies selected?

A PubMed search on the published names of the compound (MOTS-c) is filtered to records indexed to an animal or cell model, with clinical publication types, human-subject language and overview-type publications removed. The compound must be named in the title. Remaining records are ranked by title match, indexing quality and year, and the top 8 are listed after a manual read. The list was resolved against PubMed on 2026-10-12.

Does a listing here say anything about the MOTS-c Eon Peptides sells?

No. A listing records that a study was published and what it examined. It says nothing about the properties, quality or intended use of any material. What Eon Peptides does document about its own MOTS-c is on the certificate pages: lot-level identity and purity results from independent laboratories.

Related pages

For research use only. Not for human or veterinary use. Preclinical and in-vitro studies only: animal models and cell-based work indexed in PubMed. Human trials, case reports and literature overviews are excluded by rule.