Preclinical study index · Research use only

Melanotan II: preclinical and in-vitro studies

8 published studies on Melanotan II, limited by rule to animal models and cell-based (in vitro) work indexed in PubMed, spanning 2015 to 2023 across 8 journals. Human trials, case reports and literature overviews are excluded. Titles appear as published; each links to its PubMed record and, where one is registered, its DOI.

  • 8studies listed
  • 8with an animal model
  • 2with in-vitro work
  • 2015 to 2023publication years
  • 8journals

Evidence table

#YearStudyJournalModelRecord
1 2023 Melanotan-II reverses memory impairment induced by a short-term HF dietPMID 37478579 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Zebrafish model PubMed · DOI
2 2022 Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for foodPMID 36155088 Neuropeptides Mice model PubMed · DOI
3 2021 Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient micePMID 33332767 Experimental physiology Mice model PubMed · DOI
4 2020 Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan IIPMID 32674774 Analytica chimica acta Mice model PubMed · DOI
5 2019 Melanotan-II reverses autistic features in a maternal immune activation mouse model of autismPMID 30629642 PloS one Mice model PubMed · DOI
6 2018 Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptorsPMID 29812984 American journal of physiology. Endocrinology and metabolism Mice model and in vitro PubMed · DOI
7 2017 Effect of Melanotan-II on Brain Fos Immunoreactivity and Oxytocin Neuronal Activity and Secretion in RatsPMID 28009464 Journal of neuroendocrinology Rats model and in vitro PubMed · DOI
8 2015 Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J MicePMID 26108334 Alcoholism, clinical and experimental research Mice model PubMed · DOI

Studies by model

  • Mice · 6 studies
  • In vitro · 2 studies
  • Zebrafish · 1 study
  • Rats · 1 study

What this index does not include

Human research of any kind: publications typed by PubMed as human studies or case reports, and papers whose titles or abstracts describe human subjects, are removed by rule. Literature overviews, meta-analyses, editorials and letters are removed because they summarise rather than report. Papers whose titles contain usage or outcome language that would not pass this site's research-use-only copy rules are dropped rather than reworded, since a published title is a fact that cannot be edited.

Nothing on this page is a statement about effects in humans, a recommendation, or a description of the material supplied. Melanotan II is supplied for laboratory research only.

How this index is built

PubMed is searched on the names the literature uses for Melanotan II (melanotan II, melanotan-II, MT-II melanocortin), restricted to records indexed to an animal or cell model, in English, with an abstract. Clinical publication types, human-subject language and overview-type publications are excluded. The compound must be named in the title. Candidates are ranked by title match, indexing quality and year; the shortlist is read by a person before it is published, and a small blocklist holds records rejected on that read. The list was resolved on 2026-10-12 and is re-run deliberately, never on a timer.

Questions

Are there human studies of Melanotan II in this index?

No, by design. This index lists animal and cell-based research only. Publications typed as human studies, case reports or literature overviews, and papers whose titles or abstracts describe human subjects, are excluded by rule before anything is listed. Eon Peptides supplies Melanotan II for laboratory research and makes no statement about use in humans.

Which research models appear most often for Melanotan II?

Across the 8 studies listed: Mice (6), In vitro (2), Zebrafish (1), Rats (1). A model label is taken from PubMed's indexing of each paper, or from its title and abstract when the record is too new to be indexed. It describes the study, not the material.

How are the studies selected?

A PubMed search on the published names of the compound (melanotan II, melanotan-II, MT-II melanocortin) is filtered to records indexed to an animal or cell model, with clinical publication types, human-subject language and overview-type publications removed. The compound must be named in the title. Remaining records are ranked by title match, indexing quality and year, and the top 8 are listed after a manual read. The list was resolved against PubMed on 2026-10-12.

Does a listing here say anything about the Melanotan II Eon Peptides sells?

No. A listing records that a study was published and what it examined. It says nothing about the properties, quality or intended use of any material. What Eon Peptides does document about its own Melanotan II is on the certificate pages: lot-level identity and purity results from independent laboratories.

Related pages

For research use only. Not for human or veterinary use. Preclinical and in-vitro studies only: animal models and cell-based work indexed in PubMed. Human trials, case reports and literature overviews are excluded by rule.