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Detection and quantitation answer different questions

A method may detect a signal without supporting a reliable quantitative value at that level. Detection and quantitation limits therefore describe different aspects of analytical performance.

For research use only. Not for human or veterinary use.

A result below a quantitation threshold should keep its qualifier. Do not place it into an ordinary numeric average as though it were an exact measured value. State the handling rule used for such observations.

Reading checklist

Distinguish the two limits
Preserve qualified observations
Document statistical handling

Reference: Limit of quantitation.

Sources and further reading

NIST: measurement uncertainty for reference materials
NIST: reference material categories

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