Molecular data
| Molecular formula | C₃₅H₄₈N₁₀O₁₅ |
|---|---|
| Molecular weight | 848.8 Da |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Sequence length | 9 residues |
| CAS / identifier | 62568-57-4 |
| Physical form | White lyophilized powder |
| Available sizes | 5mg |
How it works
Neurotransmitter Modulation
DSIP has been reported to influence serotonin (5-HT), glutamate, dopamine and melatonin signaling — pathways tied to sleep onset and circadian timing.
Sleep Architecture
Early studies associate DSIP with increased slow-wave (delta) sleep, shorter sleep onset and improved sleep efficiency, distinct from sedative-hypnotic mechanisms.
Stress & Neuroprotection
Investigated for adaptation of the stress (HPA) axis and for protecting neurons from oxidative stress in neurodegeneration and stroke-recovery models.
What the research shows
Sleep Architecture
Studied for effects on slow-wave sleep, sleep efficiency and onset latency in animal and human models.
Stress Adaptation
Investigated for modulation of the HPA axis and stress-response regulation.
Neuroprotection
Explored for antioxidant/neuroprotective effects in models of neurodegeneration and ischemic injury.
Specification
| Also Known As | Delta Sleep-Inducing Peptide, Sleep-Promoting Peptide |
|---|---|
| Type | Nonapeptide neuropeptide |
| CAS Number | 62568-57-4 |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | 848.8 g/mol |
| Amino Acid Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Physical Appearance | White lyophilized powder |
| Purity | ≥98% (HPLC) |
| Content | 10 mg per vial |
| Appearance | White to off-white powder |
| Stability | 24 months from manufacture date when stored properly |
| Lyophilized Storage | Store at -20°C, protected from light |
| Reconstituted Storage | Store at 2-8°C, use within 30 days |
Frequently asked questions
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in the 1970s from the cerebral venous blood of rabbits in an induced sleep state, studied as an endogenous modulator of sleep and stress.
Is DSIP naturally occurring?
Yes. DSIP is an endogenous neuropeptide found in the brain, hypothalamus and other tissues, which is part of why it is of interest as a physiological sleep regulator.
What is it researched for?
Primarily sleep regulation, but also stress adaptation, neuroprotection, chronic-pain models and studies of opioid/alcohol withdrawal.
How is it stored and reconstituted?
Supplied as a lyophilized powder; store at -20°C. For laboratory use it is typically reconstituted with bacteriostatic or sterile water. Research use only.
Literature
- Isolation Characterization of a delta-EEG (sleep)-inducing peptide
- Clinical Acute and delayed effects of DSIP on human sleep behavior
- Review Delta-sleep-inducing peptide (DSIP): a review
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.